The role of renal proximal tubular cells in diabetic nephropathy

We now know that the rate of progression of diabetic nephropathy, like all progressive renal disease, correlates with the degree of corticointerstitial fibrosis. Therefore, much interest has focused on the contribution of the resident cells in the renal cortex to this process. This article reviews t...

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Bibliographic Details
Published in:Current diabetes reports 2003-11, Vol.3 (6), p.491-496
Main Author: Phillips, Aled O
Format: Article
Language:English
Subjects:
Animals
Diabetes
Diabetic Nephropathies - pathology
Diabetic Nephropathies - physiopathology
Diabetic nephropathy
Humans
Kidney Cortex - pathology
Kidney Cortex - physiopathology
Kidney Failure, Chronic - parasitology
Kidney Failure, Chronic - prevention & control
Kidney Tubules, Proximal - pathology
Kidney Tubules, Proximal - physiopathology
Transforming Growth Factor beta - physiology
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Summary:We now know that the rate of progression of diabetic nephropathy, like all progressive renal disease, correlates with the degree of corticointerstitial fibrosis. Therefore, much interest has focused on the contribution of the resident cells in the renal cortex to this process. This article reviews the evidence that the epithelial cells of the proximal tubule are major players in orchestrating events in the corticointerstitium in diabetic nephropathy. More specifically, it addresses their role in extracellular matrix turnover, generation of cytokines, and recruitment of inflammatory cells, as well as examining the concept that they are the source of the interstitial myofibroblasts, which are the principal mediators of the fibrotic process.
ISSN:1534-4827
1539-0829
DOI:10.1007/s11892-003-0013-1