Acute effects of cardiac resynchronization therapy on left ventricular Doppler indices in patients with congestive heart failure

Background Patients with heart failure frequently exhibit intraventricular conduction delays, which contribute to asynchronous contraction patterns and impaired hemodynamic performance. Cardiac resynchronization therapy (CRT) with biventricular (BV) and left ventricular (LV) pacing has been shown to...

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Bibliographic Details
Published in:The American heart journal 2002-01, Vol.143 (1), p.34-44
Main Authors: Breithardt, Ole-A., Stellbrink, Christoph, Franke, Andreas, Balta, Osman, Diem, Björn H., Bakker, Patricia, Sack, Stefan, Auricchio, Angelo, Pochet, Thierry, Salo, Rodney
Format: Article
Language:English
Subjects:
Aging
Analysis of Variance
Atrioventricular Node - physiopathology
Biological and medical sciences
Cardiac Pacing, Artificial - methods
Cardiology. Vascular system
Cardiomyopathy
Cardiomyopathy, Dilated - complications
Cardiomyopathy, Dilated - diagnostic imaging
Cardiovascular disease
Colorectal cancer
Cross-Over Studies
Echocardiography, Doppler
Female
Heart
Heart failure
Heart Failure - diagnostic imaging
Heart Failure - physiopathology
Heart Failure - therapy
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Male
Medical sciences
Middle Aged
Myocardial Contraction - physiology
Ostomy
Pacemaker, Artificial
Single-Blind Method
Vegetables
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - physiopathology
Ventricular Dysfunction, Left - therapy
Ventricular Dysfunction, Right - diagnostic imaging
Ventricular Dysfunction, Right - physiopathology
Ventricular Dysfunction, Right - therapy
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Summary:Background Patients with heart failure frequently exhibit intraventricular conduction delays, which contribute to asynchronous contraction patterns and impaired hemodynamic performance. Cardiac resynchronization therapy (CRT) with biventricular (BV) and left ventricular (LV) pacing has been shown to improve both hemodynamic and clinical performance. This study investigated the effects of CRT on LV Doppler indices in these patients. Methods and Results Thirty-two patients with advanced heart failure (New York Heart Association class ≥III, QRS >120 milliseconds, PR interval >150 milliseconds) were studied 4 weeks after implantation of a CRT system. Doppler echocardiography was conducted in 3 separate CRT modes, right ventricular, LV, and BV stimulation at 3 different atrioventricular delays. CRT resulted in significant improvement of Doppler parameters such as filling time (FT, 313 ± 111 milliseconds at baseline → 363 ± 154 milliseconds [BV], P
ISSN:0002-8703
1097-6744
DOI:10.1067/mhj.2002.119616