Fluorescence studies on PAMAM dendrimers interactions with bovine serum albumin

Polyamidoamine (PAMAM) dendrimers (generation 3.5 and 4) interaction with bovine serum albumin (BSA) was studied. The intensity of intrinsic fluorescence of two tryptophan residues and a shift in wavelength of their emission maxima were chosen as indicators of protein conformational changes. It is s...

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Bibliographic Details
Published in:Bioelectrochemistry (Amsterdam, Netherlands) Netherlands), 2002, Vol.55 (1), p.33-35
Main Authors: Klajnert, B, Bryszewska, M
Format: Article
Language:English
Subjects:
Bovine serum albumin
Dendrimers
Fluorescence quenching
PAMAM dendrimers
Polyamines - metabolism
Protein Binding
Serum Albumin, Bovine - metabolism
Spectrometry, Fluorescence - methods
Stern–Volmer plot
Tryptophan
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Summary:Polyamidoamine (PAMAM) dendrimers (generation 3.5 and 4) interaction with bovine serum albumin (BSA) was studied. The intensity of intrinsic fluorescence of two tryptophan residues and a shift in wavelength of their emission maxima were chosen as indicators of protein conformational changes. It is shown that the generation 4 has a greater impact on spectral properties of serum albumin than generation 3.5.
ISSN:1567-5394
1878-562X
DOI:10.1016/S1567-5394(01)00170-0