Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain‐derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffe...

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Bibliographic Details
Published in:Annals of neurology 2002-01, Vol.51 (1), p.133-136
Main Authors: Momose, Yoshio, Murata, Miho, Kobayashi, Kazuhiro, Tachikawa, Masaji, Nakabayashi, Yuko, Kanazawa, Ichiro, Toda, Tatsushi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Brain-Derived Neurotrophic Factor - genetics
Cytochrome P-450 Enzyme System - genetics
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dopamine - genetics
Female
Genetic Predisposition to Disease
Homozygote
Humans
Male
Medical sciences
Middle Aged
Neurology
Parkinson Disease - genetics
Polymorphism, Single Nucleotide - genetics
Thiolester Hydrolases - genetics
Ubiquitin Thiolesterase
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Summary:We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain‐derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (χ2 = 5.46) and confirmed an association with the S18Y polymorphism of the UCH‐L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.10079