Biomechanical effects of intraspecimen variations in tissue modulus for trabecular bone

Although recent nanoindentation studies have revealed the existence of substantial variations in tissue modulus within single specimens of trabecular bone, little is known regarding the biomechanical effects of such intraspecimen variations. In this study, high-resolution finite element modeling was...

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Bibliographic Details
Published in:Journal of biomechanics 2002-02, Vol.35 (2), p.237-246
Main Authors: Jaasma, Michael J., Bayraktar, Harun H., Niebur, Glen L., Keaveny, Tony M.
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Apparent modulus
Biomechanical Phenomena
Bone
Cancellous bone
Cattle
Compressive strength
Computer simulation
Elastic moduli
Elasticity
Female
Femur - physiology
Finite Element Analysis
Finite element method
Finite element modeling
Genetic Variation
Humans
Indentation
Male
Models, Biological
Nonlinear Dynamics
Tensile Strength
Thoracic Vertebrae - physiology
Tibia - physiology
Tissue modulus
Weight-Bearing - physiology
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Summary:Although recent nanoindentation studies have revealed the existence of substantial variations in tissue modulus within single specimens of trabecular bone, little is known regarding the biomechanical effects of such intraspecimen variations. In this study, high-resolution finite element modeling was used to investigate these effects. With limited literature information on the spatial distribution of intraspecimen variations in tissue modulus, two plausible spatial distributions were evaluated. In addition, three specimens (human femoral neck, human vertebral body, and bovine proximal tibia) were studied to assess the role of trabecular architecture. Results indicated that for all specimen/distribution combinations, the apparent modulus of the whole specimen decreased nonlinearly with increasing coefficient of variation (COV) of tissue modulus within the specimen. Apparent modulus decreased by
ISSN:0021-9290
1873-2380
DOI:10.1016/S0021-9290(01)00193-2