Postinflammatory sarcoma in cats

Histological examination of 38 nodular formations extirpated from the site of vaccine administration to cats disclosed 25 cases of sarcoma and 13 of granuloma. Average age of the cats bearing sarcoma was 8.75 years whereas granuloma occurred at average age of 1.9 year. This age-relationship of the l...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2003-09, Vol.55 (2), p.167-172
Main Author: JELINEK, Frantisek
Format: Article
Language:English
Subjects:
Acid Phosphatase - analysis
Alkaline Phosphatase - analysis
Animals
Biological and medical sciences
Carboxylesterase - analysis
Cat
Cat Diseases - pathology
Cats
Dermatology
enzyme histochemistry
Female
Immunocompromised Host
Immunoenzyme Techniques - veterinary
immunohistochemistry
Inflammation - complications
Inflammation - enzymology
Inflammation - pathology
Inflammation - veterinary
local reaction
Male
Medical sciences
sarcoma
Sarcoma - enzymology
Sarcoma - etiology
Sarcoma - pathology
Sarcoma - veterinary
Soft Tissue Neoplasms - enzymology
Soft Tissue Neoplasms - etiology
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - veterinary
Tumors of the skin and soft tissue. Premalignant lesions
Vaccination - adverse effects
Vaccination - veterinary
vaccine
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Summary:Histological examination of 38 nodular formations extirpated from the site of vaccine administration to cats disclosed 25 cases of sarcoma and 13 of granuloma. Average age of the cats bearing sarcoma was 8.75 years whereas granuloma occurred at average age of 1.9 year. This age-relationship of the lesions, as well as their similar morphologic features indicated a progression of chronic inflammatory changes to tumors. Similar tumors were diagnosed in one cat with “posttraumatic ocular sarcoma” and in the uterus of female-cat with long-standing pyometra. These two cats were 15 and 8 years old, respectively. Experimental study of local reaction 21 days after administration of commercial, lipid-adjuvanted vaccine revealed in young cats (age 9 months) a reaction to immunogen, whereas in old animals (age 10 to 15 years) there was a reaction to foreign material. The data suggest that chronic inflammation and age-related immunodeficiency are instrumental in pathogenesis of the vaccine-associated sarcoma
ISSN:0940-2993
1618-1433
DOI:10.1078/0940-2993-00307