Rho GTPases and cadherin-based cell adhesion in skeletal muscle development

The small GTPases of the Rho subfamily (RhoA, Rac1 and Cdc42) are signaling molecules involved in cytoskeleton remodeling and gene transcription. Their activities are important for many cellular processes, including myogenesis. Classical cadherin adhesion molecules are key determinants of cell recog...

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Bibliographic Details
Published in:Journal of muscle research and cell motility 2003-01, Vol.24 (4-6), p.309-313
Main Authors: Charrasse, Sophie, Causeret, Marie, Comunale, Franck, Bonet-Kerrache, Armelle, Gauthier-Rouvière, Cécile
Format: Article
Language:English
Subjects:
Animals
Cadherins - chemistry
Cadherins - metabolism
Cell adhesion & migration
Cell Adhesion - physiology
Humans
Muscle, Skeletal - cytology
Muscle, Skeletal - growth & development
Muscle, Skeletal - metabolism
Proteins
rho GTP-Binding Proteins - chemistry
rho GTP-Binding Proteins - metabolism
Signal transduction
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Summary:The small GTPases of the Rho subfamily (RhoA, Rac1 and Cdc42) are signaling molecules involved in cytoskeleton remodeling and gene transcription. Their activities are important for many cellular processes, including myogenesis. Classical cadherin adhesion molecules are key determinants of cell recognition and tissus morphogenesis and act as adhesion-activated signaling receptors. Rho GTPases have emerged as key mediators of their activity. Not only signal transduction pathways link cadherins to Rho GTPases but also Rho GTPases to cadherins. We focus in this review on the role of cadherins and Rho GTPases in normal myogenesis as well as in pathological development of rhabdomyosarcoma.
ISSN:0142-4319
1573-2657
DOI:10.1023/A:1025429924231