Evaluation of Pulsatile and Nonpulsatile Flow in Microvessels of the Bulbar Conjunctiva in the Goat with an Undulation Pump Artificial Heart

: This study has three purposes, as follows. The first is to develop a microscopic system to observe the microcirculation of animals implanted with an artificial heart. The second is to investigate the influence of flow pattern change from pulsatile to nonpulsatile on the microcirculation. The third...

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Bibliographic Details
Published in:Artificial organs 2003-10, Vol.27 (10), p.875-881
Main Authors: Baba, Atsushi, Dobsak, Petr, Mochizuki, Shuichi, Saito, Itsuro, Isoyama, Takashi, Takiura, Koki, Shibata, Masahiro, Abe, Yusuke, Chinzei, Tsuneo, Vasku, Jaromir, Imachi, Kou
Format: Article
Language:English
Subjects:
Animals
Artificial heart
Bulbar conjunctiva
Endothelium-derived nitric oxide
Female
Goats
Heart, Artificial
Hemodynamics
Microcirculation
Microcirculation - physiology
nitric oxide
Nitric Oxide - metabolism
Nonpulsatile flow
Pulsatile flow
Pulsatile Flow - physiology
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Summary:: This study has three purposes, as follows. The first is to develop a microscopic system to observe the microcirculation of animals implanted with an artificial heart. The second is to investigate the influence of flow pattern change from pulsatile to nonpulsatile on the microcirculation. The third is to study the effects of pulsatility in blood flow on endothelium‐derived nitric oxide release in the microvasculature. When the flow pattern was changed from pulsatile to nonpulsatile, the velocity of erythrocytes in many capillaries dropped and remained at a low level, and the number of perfused capillaries decreased. After the flow pattern was returned to pulsatile, the velocity of erythrocytes recovered to the initial level. In many cases, the flow of nonperfused capillaries recovered to the initial level as well. Also, the pulsatile flow enhances the basal and flow‐stimulated endothelium‐derived nitric oxide release in microvessels.
ISSN:0160-564X
1525-1594
DOI:10.1046/j.1525-1594.2003.00027.x