Use of an "acetaldehyde clamp" in the determination of low-KM aldehyde dehydrogenase activity in H4-II-E-C3 rat hepatoma cells

The high-affinity (K(M)

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Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2003-08, Vol.31 (1-2), p.19-24
Main Authors: Moncada, Claudio, Fuentes, Nelson, Lladser, Alvaro, Encina, Gonzalo, Sapag, Amalia, Karahanian, Eduardo, Israel, Yedy
Format: Article
Language:English
Subjects:
Acetaldehyde - metabolism
Acetaldehyde - pharmacology
Aldehyde Dehydrogenase - metabolism
Aldehyde Dehydrogenase, Mitochondrial
Animals
Carcinoma, Hepatocellular - enzymology
Cell Line, Tumor
Dose-Response Relationship, Drug
Enzyme Activation - drug effects
Enzyme Activation - physiology
Enzyme Inhibitors - pharmacology
Ethanol - metabolism
Ethanol - pharmacology
Kinetics
Rats
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Description
Summary:The high-affinity (K(M)
ISSN:0741-8329
DOI:10.1016/j.alcohol.2003.06.004