Nasal involvement in allergic asthma

Even since the late 19th century, a relationship has been suspected between upper airway disease and the subsequent development or aggravation of asthma symptoms. To date, it has been generally accepted that pathologic conditions of the upper airways, e.g. allergic rhinitis, chronic sinusitis and na...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2003-12, Vol.58 (12), p.1235-1243
Main Authors: Braunstahl, G.‐J., Fokkens, W.
Format: Article
Language:English
Subjects:
allergic rhinitis
asthma
Asthma - complications
Asthma - immunology
Biological and medical sciences
Chronic obstructive pulmonary disease, asthma
clinical expression
Humans
link
Medical sciences
mucosal inflammation
Nasal Polyps - complications
Nasal Polyps - immunology
Non tumoral diseases
Otorhinolaryngology. Stomatology
Pneumology
Respiratory Mucosa - immunology
Rhinitis - complications
Rhinitis - immunology
Sinusitis - complications
Sinusitis - immunology
systemic interaction
treatment
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Even since the late 19th century, a relationship has been suspected between upper airway disease and the subsequent development or aggravation of asthma symptoms. To date, it has been generally accepted that pathologic conditions of the upper airways, e.g. allergic rhinitis, chronic sinusitis and nasal polyposis, may influence the lower airways. However, the mechanisms underlying this relationship were, for a long time, poorly understood. Recently, evidence has been accumulating which indicates a systemic connection as one of the responsible mechanisms in nasobronchial crosstalk. In this review, the pathophysiologic and immunologic aspects of the interaction between upper and lower airways will be discussed.
ISSN:0105-4538
1398-9995
DOI:10.1046/j.0105-4538.2003.00354.x