Serum uric acid as an independent predictor of mortality in patients with angiographically proven coronary artery disease

It is a matter of controversy as to whether uric acid is an independent predictor of mortality in patients with coronary artery disease (CAD) or whether it represents only an indirect marker of adverse outcome by reflecting the association between uric acid and other cardiovascular risk factors. The...

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Bibliographic Details
Published in:The American journal of cardiology 2002, Vol.89 (1), p.12-17
Main Authors: Bickel, Christoph, Rupprecht, Hans J, Blankenberg, Stefan, Rippin, Gerd, Hafner, Gerd, Daunhauer, Alexander, Hofmann, Klaus-Peter, Meyer, Jürgen
Format: Article
Language:English
Subjects:
Acids
Adult
Aged
Biological and medical sciences
Biomarkers - blood
Blood
Blood vessels
Cardiology. Vascular system
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - mortality
Coronary heart disease
Coronary vessels
Disease
Female
Germany - epidemiology
Heart
Humans
Male
Medical sciences
Middle Aged
Mortality
Predictive Value of Tests
Proportional Hazards Models
Risk Factors
Survival Analysis
Uric Acid - blood
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Summary:It is a matter of controversy as to whether uric acid is an independent predictor of mortality in patients with coronary artery disease (CAD) or whether it represents only an indirect marker of adverse outcome by reflecting the association between uric acid and other cardiovascular risk factors. Therefore, we studied the influence of uric acid levels on mortality in patients with CAD. In 1,017 patients with angiographically proven CAD, classic risk factors and uric acid levels were determined at enrollment. A follow-up over a median of 2.2 years (maximum 3.1) was performed. Death from all causes was defined as an end point of the study. In CAD patients with uric acid levels 433 μmol/L (7.1 mg/dl) (highest quartile), the mortality rate increased from 3.4% to 17.1% (fivefold increase). After adjustment for age, both sexes demonstrated an increased risk for death with increasing uric acid levels (female patients: hazard ratio [HR] 1.30, 95% confidence intervals [CI] 1.14 to 1.49, p ≤0.001; male patients: HR 1.39 [95% CI 1.21 to 1.59], p ≤0.001). In multivariate Cox regression analysis performed with 12 variables that influence overall mortality—including diuretic use—elevated levels of uric acid demonstrated an independent, significant positive relation to overall mortality (HR 1.23 [95% CI 1.11 to 1.36], p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(01)02155-5