Treatment of Uncomplicated Falciparum Malaria in Southern Vietnam: Can Chloroquine or Sulfadoxine-Pyrimethamine Be Reintroduced in Combination with Artesunate?

The effectiveness of chloroquine or sulfadoxine-pyrimethamine administered with artesunate for treating uncomplicated falciparum malaria was assessed in 2 Vietnamese provinces where the sensitivity of parasites in vitro to conventional therapies had increased with the removal of drug pressure. In th...

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Bibliographic Details
Published in:Clinical infectious diseases 2003-12, Vol.37 (11), p.1461-1466
Main Authors: Huong, Nguyen Mai, Davis, Timothy M. E., Cox-Singh, Janet, Hewitt, Sean, Toan, Tran Quoc, Kim, Tran Bach, Hanh, Nguyen Thi, Phuong, Vo Nhu, Nhan, Doan Hanh, Cong, Le Dinh
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials
Antimalarials - therapeutic use
Antiparasitic agents
Artemisinins
Artemisinins - therapeutic use
artesunate
Biological and medical sciences
Child
chloroquine
Chloroquine - therapeutic use
Drug Combinations
Drug Therapy, Combination
Falciparum malaria
Female
Genotype
Human protozoal diseases
Humans
Infections
Infectious diseases
Major Articles
Malaria
Malaria, Falciparum - drug therapy
Male
Medical sciences
Medical treatment failures
Parasitemia
Parasites
Parasitic diseases
Pharmacology. Drug treatments
Plasmodium falciparum
Polymerase chain reaction
Protozoal diseases
Pyrimethamine - therapeutic use
Relapse
Sesquiterpenes - therapeutic use
Sulfadoxine - therapeutic use
sulfadoxine-pyrimethamine
Treatment Outcome
Vietnam
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Summary:The effectiveness of chloroquine or sulfadoxine-pyrimethamine administered with artesunate for treating uncomplicated falciparum malaria was assessed in 2 Vietnamese provinces where the sensitivity of parasites in vitro to conventional therapies had increased with the removal of drug pressure. In the province of Dac Lac, where potential malaria exposure begins at birth, 57 subjects (mean age, 9.6 years) were randomized to receive artesunate-chloroquine (group 1) or artesunate-sulfadoxine-pyrimethamine (group 2). In the province of Binh Phuoc, 66 nonimmune workers and their relatives (mean age, 24.2 years) were similarly randomized. By day 28 of follow-up, >96% of Dac Lac patients and
ISSN:1058-4838
1537-6591
DOI:10.1086/379323