DNase I: structure, function, and use in medicine and forensic science

In this review, available structural data of deoxyribonucleases I (DNases I) from several mammalian species, hen, snake and frog are summarized. Comparative studies on enzymatic and immunological properties and glycosylation are discussed, and several evolutionary conclusions are presented. Over the...

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Bibliographic Details
Published in:Legal Medicine 2001-06, Vol.3 (2), p.69-83
Main Authors: Kishi, Koichiro, Yasuda, Toshihiro, Takeshita, Haruo
Format: Article
Language:English
Subjects:
Deoxyribonuclease I
Dried agarose film overlay
Forensic science
Medical genetics
Single radial enzyme diffusion
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Summary:In this review, available structural data of deoxyribonucleases I (DNases I) from several mammalian species, hen, snake and frog are summarized. Comparative studies on enzymatic and immunological properties and glycosylation are discussed, and several evolutionary conclusions are presented. Over the past decade, the availability of new investigative tools, including sensitive methods of electrophoresis, detection and determination, and genetically modified DNase I models has resulted in a clearer understanding of the molecular mechanisms that connect the function and usefulness of DNase I in medicine and forensic science.
ISSN:1344-6223
1873-4162
DOI:10.1016/S1344-6223(01)00004-9