Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions

Fractional flow reserve (FFR) and coronary blood flow velocity reserve (CFR) represent physiological quantities used to evaluate coronary lesion severity and to make clinical decisions. A comparison between the outcomes of both diagnostic techniques has not been performed in a large cohort of patien...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-01, Vol.103 (2), p.184-187
Main Authors: MEUWISSEN, Martijn, CHAMULEAU, Steven A. J, SIEBES, Maria, SCHOTBORGH, Carl E, KOCH, Karel T, DE WINTER, Robbert J, BAX, Matthijs, DE JONG, Angelina, SPAAN, Jos A. E, PIEK, Jan J
Format: Article
Language:English
Subjects:
Angina Pectoris - etiology
Biological and medical sciences
Blood Flow Velocity
Cardiac Catheterization
Cardiology. Vascular system
Cohort Studies
Coronary Angiography
Coronary Circulation
Coronary heart disease
Coronary Stenosis - complications
Coronary Stenosis - diagnosis
Coronary Stenosis - physiopathology
Heart
Humans
Medical sciences
Microcirculation
Ultrasonography, Interventional
Vascular Resistance
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Summary:Fractional flow reserve (FFR) and coronary blood flow velocity reserve (CFR) represent physiological quantities used to evaluate coronary lesion severity and to make clinical decisions. A comparison between the outcomes of both diagnostic techniques has not been performed in a large cohort of patients with intermediate coronary lesions. FFR and CFR were assessed in 126 consecutive patients with 150 intermediate coronary lesions (between 40% and 70% diameter stenosis by visual assessment). Agreement between outcomes of FFR and CFR, categorized at cut-off values of 0.75 and 2.0, respectively, was observed in 109 coronary lesions (73%), whereas discordant outcomes were present in 41 lesions (27%). In 26 of these 41 lesions, FFR was or=2.0 (group A); in the remaining 15 lesions, FFR was >or=0.75 and CFR
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.103.2.184