Calcineurin anchoring and cell signaling

The targeting of phosphatase PP2B or calcineurin toward certain substrates synchronizes a variety of physiological processes. This review emphasizes how the targeting of calcineurin through interaction with various anchoring proteins facilitates phosphatase regulation of T-cell activation, neuronal...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2003-11, Vol.311 (4), p.1111-1115
Main Authors: Dodge, Kimberly L, Scott, John D
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Calcineurin - metabolism
Cardiomegaly - metabolism
DNA-Binding Proteins - metabolism
Humans
Intracellular Signaling Peptides and Proteins
Muscle Proteins - metabolism
NFATC Transcription Factors
Nuclear Proteins
Protein Binding
Receptors, AMPA - metabolism
Signal Transduction - physiology
Transcription Factors - metabolism
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Description
Summary:The targeting of phosphatase PP2B or calcineurin toward certain substrates synchronizes a variety of physiological processes. This review emphasizes how the targeting of calcineurin through interaction with various anchoring proteins facilitates phosphatase regulation of T-cell activation, neuronal excitability and cardiac hypertrophy.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2003.09.040