Parasite antigenaemia and IgG4 antibodies to a filarial protease in an endemic human population in India

Levels of circulating filarial antigen (Og4C3) and IgG4 antibodies to a filarial protease were determined in subjects of Wuchereria bancrofti exposed sera from Orissa, India. In addition to all individuals with antigenaemia (microfilaraemia), IgG4 antibodies were also detected in some individuals wi...

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Bibliographic Details
Published in:Journal of helminthology 2003-12, Vol.77 (4), p.287-290
Main Authors: Bal, M.S., Beuria, M.K., Mandal, N.N., Das, M.K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Antigens, Helminth - blood
Biological and medical sciences
Child
Elephantiasis, Filarial - immunology
Endemic Diseases
Endopeptidases - immunology
Filariasis - diagnosis
Filariasis - epidemiology
Filariasis - immunology
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Host parasite relation
pathogenicity
Humans
Immunoglobulin G - blood
India - epidemiology
Invertebrates
Nemathelminthia. Plathelmintha
Risk Factors
Serologic Tests - methods
Wuchereria bancrofti - enzymology
Wuchereria bancrofti - immunology
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Summary:Levels of circulating filarial antigen (Og4C3) and IgG4 antibodies to a filarial protease were determined in subjects of Wuchereria bancrofti exposed sera from Orissa, India. In addition to all individuals with antigenaemia (microfilaraemia), IgG4 antibodies were also detected in some individuals without antigenaemia. A 2-year longitudinal follow-up indicated that IgG4 seropositivity in asymptomatic amicrofilaraemics could be a risk factor for acquiring infection (antigenaemia).
ISSN:0022-149X
1475-2697
DOI:10.1079/JOH2003198