Association between serum undercarboxylated osteocalcin and bone density and/or quality in early postmenopausal women

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2003-11, Vol.19 (11), p.1001-1003
• Main Authors: Žofková, Ivana, Hill, Martin, Palička, Vladimír
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; Aged; Biological and medical sciences; Biomechanical Phenomena; Body Mass Index; Body weight; Bone and Bones - physiology; Bone Density; Bone Remodeling; Bones; Czech Republic; Female; Humans; Injuries of the limb. Injuries of the spine; Medical sciences; Menopause; Middle Aged; Older people; Osteocalcin - blood; Osteocalcin - chemistry; Osteoporosis; Postmenopause; Traumas. Diseases due to physical agents
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/S0899-9007(03)00179-5

The extensive prospective cohort study showed that ucOC predicts hip fracture risk independently of femoral neck BMD in women older than 75 y.2 A prospective study found that elderly women with an increased serum ucOC have a six-fold increased risk of sustaining a hip fracture during follow-up as compared with those with normal serum ucOC.6 Moreover, logistic regression has indicated the correlation of serum ucOC to hip fractures when age and parathyroid hormone levels are included in the model.7 The predictive importance of serum ucOC and/or ucOC/OC ratio for the occurrence of fractures in elderly subjects has been suggested by others.8 The absence of a relation between serum ucOC/OC and BMD in our study contrasts with the results obtained in a comparable sample of elderly women.5 The latter study showed that ucOC has the highest predictive value for BMD when age and body weight are included in the equation, indicating that serum ucOC is a determinant of BMD of the hip in elderly women. [...]our postmenopausal women were substantially younger, and only one had a history of hip fracture, whereas the others had a spectrum of fractures of different localizations. [...]serum ucOC appears to be associated with particular types of fractures.