Non-specific immunity-enhancing effects of tryptic casein hydrolysate versus Fermosorb for treatment/prophylaxis of newborn calf colibacillosis

The effects of treatment/prophylaxis of newborn calf colibacillosis with tryptic casein hydrolysate (TCH), recently shown to be a novel type of antimicrobial acting through stimulation of the microbial autolytic system, versus an authorized veterinary drug, Fermosorb, were evaluated. Both products s...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 2003-11, Vol.39 (2), p.155-161
Main Authors: Biziulevičius, Gediminas A., Žukait≐, Vilhelmina, Normantien≐, Teresa, Biziulevičien≐, Gen≐, Arestov, Ivan G.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Animals
Animals, Newborn
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antimicrobial activity
Biological and medical sciences
Blood Protein Electrophoresis
Calcium - blood
Caseins - immunology
Caseins - pharmacology
Caseins - therapeutic use
Cattle
Cattle Diseases - drug therapy
Cattle Diseases - microbiology
Cattle Diseases - prevention & control
Enzymotherapy
Erythrocyte Count
Escherichia coli Infections - drug therapy
Escherichia coli Infections - prevention & control
Escherichia coli Infections - veterinary
Fermosorb
Fundamental and applied biological sciences. Psychology
g-globulin
Hematocrit
Hemoglobins - analysis
Immunostimulatory activity
Intestinal Diseases - drug therapy
Intestinal Diseases - microbiology
Intestinal Diseases - prevention & control
Intestinal Diseases - veterinary
Leukocyte Count
Microbiology
Muramidase - blood
Newborn calf colibacillosis
Phosphorus - blood
Subtilisins - pharmacology
Subtilisins - therapeutic use
Tryptic casein hydrolysate
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Summary:The effects of treatment/prophylaxis of newborn calf colibacillosis with tryptic casein hydrolysate (TCH), recently shown to be a novel type of antimicrobial acting through stimulation of the microbial autolytic system, versus an authorized veterinary drug, Fermosorb, were evaluated. Both products showed similar high therapeutic and prophylactic efficacies, but hematological indices and daily weight gain of cured/protected animals were better with TCH. The differences in hemoglobin and hematocrit levels, total protein, γ-globulin and sulfhydryl group quantities, bactericidal and lysozyme activities as well as daily weight gain at the end of treatment/prophylaxis were statistically significant ( P
ISSN:0928-8244
1574-695X
DOI:10.1016/S0928-8244(03)00222-0