Conversion of various aromatic compounds by resting cells of Fusarium moniliforme strain MS31

Resting cells of Fusarium moniliforme strain MS31 convert propylbenzene to 1-phenylpropanol with high regio- and stereospecificity. To elucidate the scope of substrate acceptability by the fungus, we used various aromatic compounds for the bioconversion. The fungus hydroxylated various alkylbenzenes...

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Bibliographic Details
Published in:Journal of bioscience and bioengineering 2001, Vol.92 (4), p.381-384
Main Authors: Uzura, Atsuko, Katsuragi, Tohoru, Tani, Yoshiki
Format: Article
Language:English
Subjects:
alkylbenzenes
AROMATIC COMPOUNDS
arylalkanes
benzylic alcohols
BIOCONVERSION
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
FUSARIUM
Fusarium moniliforme
HYDROXYLATION
Methods. Procedures. Technologies
stereoselective bioconversion
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Summary:Resting cells of Fusarium moniliforme strain MS31 convert propylbenzene to 1-phenylpropanol with high regio- and stereospecificity. To elucidate the scope of substrate acceptability by the fungus, we used various aromatic compounds for the bioconversion. The fungus hydroxylated various alkylbenzenes at the benzylic position to produce optically active alcohols. Butylbenzene was converted to nonbenzylic alcohols. In all cases, the R absolute configuration of products was more abundant. Aromatic compounds with linear side chains and (1-methylethyl)benzene were converted to their corresponding alcohols with an enantiomeric excess of 94% to 100%. Further oxidation of the alcohols was detected, but it was weak.
ISSN:1389-1723
1347-4421
DOI:10.1016/S1389-1723(01)80243-7