Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers

The number of clinical studies on gamma interferon (IFN-γ), tumor necrosis factor-alpha (TNF-α) and interleukin-4 (IL-4) in human brucellosis is limited. The present study was focused on IFN-γ, TNF-α and IL-4 levels in acute brucellosis cases, in the acute phase and at the end of the treatment. The...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 2003-11, Vol.39 (2), p.149-153
Main Authors: Demirdag, Kutbettin, Ozden, Mehmet, Kalkan, Ahmet, Godekmerdan, Ahmet, Sirri Kilic, S
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Anti-Bacterial Agents - therapeutic use
Biological and medical sciences
Biomarkers - blood
Blood Sedimentation
Brucella
Brucellosis
Brucellosis - drug therapy
Brucellosis - immunology
Brucellosis - microbiology
Brucellosis - physiopathology
C-reactive protein
C-Reactive Protein - analysis
Cytokine
Female
Fundamental and applied biological sciences. Psychology
Humans
Inflammatory marker
Interferon-gamma - blood
Interleukin-4 - blood
Male
Microbiology
Middle Aged
Treatment
Tumor Necrosis Factor-alpha - analysis
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Summary:The number of clinical studies on gamma interferon (IFN-γ), tumor necrosis factor-alpha (TNF-α) and interleukin-4 (IL-4) in human brucellosis is limited. The present study was focused on IFN-γ, TNF-α and IL-4 levels in acute brucellosis cases, in the acute phase and at the end of the treatment. The relation of these cytokines to traditional inflammation markers was also investigated. The study included 27 cases of acute brucellosis and 20 healthy volunteers who had no complaints. It was found that mean IFN-γ and TNF-α levels, CRP (C-reactive protein) levels and ESR (erythrocyte sedimentation rate) values were significantly higher in acute brucellosis cases as compared to post-treatment values and values measured in the control group. In addition, IFN-γ and TNF-α levels measured in the acute phase correlated with the increase in CRP levels and ESR values. Our results confirmed that IFN-γ and TNF-α are involved in the pathophysiology of brucellosis and are closely related to the inflammatory activation of the disease. In view of the present findings, it is suggested that IFN-γ and TNFα may be used for monitoring brucellosis.
ISSN:0928-8244
1574-695X
DOI:10.1016/S0928-8244(03)00207-4