Cobalamin Status and Its Biochemical Markers Methylmalonic Acid and Homocysteine in Different Age Groups from 4 Days to 19 Years

Recent data indicate that cobalamin and folate status, including the metabolic markers methylmalonic acid (MMA) and total homocysteine (tHcy), undergo marked changes during childhood, particularly during the first year. Serum cobalamin, serum and whole-blood folate, and plasma MMA and tHcy were dete...

Full description

Saved in:
Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2003-12, Vol.49 (12), p.2067-2075
Main Authors: Monsen, Anne-Lise Bjorke, Refsum, Helga, Markestad, Trond, Ueland, Per Magne
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Biomarkers - blood
Child
Child, Preschool
Cross-Sectional Studies
Female
Homocysteine - blood
Humans
Infant
Infant, Newborn
Infants
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Metabolic diseases
Methylmalonic Acid - blood
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Reference Values
Vitamin B 12 - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent data indicate that cobalamin and folate status, including the metabolic markers methylmalonic acid (MMA) and total homocysteine (tHcy), undergo marked changes during childhood, particularly during the first year. Serum cobalamin, serum and whole-blood folate, and plasma MMA and tHcy were determined in a cross-sectional study of 700 children, ages 4 days to 19 years. During the first 6 months, serum cobalamin was lower than and plasma MMA, tHcy, and serum folate were higher than the concentrations detected in the other age groups. In infants 6 weeks to 6 months of age, median MMA and tHcy concentrations were >0.78 and >75 micro mol/L, respectively. In older children (>6 months), serum cobalamin peaked at 3-7 years and then decreased, median plasma MMA remained low (
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2003.019869