Prognostic value of microvessel density in invasive ductal carcinoma of the breast

Although the prognostic value of microvessel density (MVD) has been studied in breast cancer, the results still remain controversial. Paraffin embedded sections of invasive ductal carcinoma of the breast were immunohistochemically stained for factor VIII- related antigen in 252 patients with a media...

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Bibliographic Details
Published in:Breast cancer (Tokyo, Japan) Japan), 2003-10, Vol.10 (4), p.312-319
Main Authors: Tsutsui, Shinichi, Kume, Masazumi, Era, Shoichi
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Breast Neoplasms - blood supply
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Carcinoma, Ductal - blood supply
Carcinoma, Ductal - secondary
Carcinoma, Ductal - therapy
Disease-Free Survival
Female
Humans
Immunohistochemistry
Male
Microcirculation
Middle Aged
Predictive Value of Tests
Prognosis
Recurrence
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Summary:Although the prognostic value of microvessel density (MVD) has been studied in breast cancer, the results still remain controversial. Paraffin embedded sections of invasive ductal carcinoma of the breast were immunohistochemically stained for factor VIII- related antigen in 252 patients with a median follow-up duration of 7.0 years. MVD quantification of the three most vascular areas at a magnification of x 200 was performed. The 252 patients were stratified into high and low MVD groups according to a cut-off value that was the upper one-third MVD value of all patients. The patients with a high MVD had a significantly worse outcome in terms of both disease free survival (DFS) (p< 0.0001) and overall survival (OS) (p= 0.0012) compared with those with a low MVD. The same effects were seen in patients with lymph node negative as well as positive breast cancer. Multivariate analyses indicated the nodal status, nuclear grade and MVD (p= 0.0001) to be independent prognostic factors for the DFS, while the nodal status, estrogen receptor status, tumor size and MVD (p= 0.0006) were independent prognostic factors for the OS. MVD was found to be an independent prognostic indicator of recurrence and death for breast cancer, and is therefore considered to be a useful factor for selecting high risk patients to receive adjuvant therapies.
ISSN:1340-6868
1880-4233
DOI:10.1007/BF02967651