Involvement of caveolae and caveolae-like domains in signalling, cell survival and angiogenesis

Caveolae, the flask-shaped membrane invaginations abundant in endothelial cells, have acquired a prominent role in signal transduction. Evidence, that events occurring in caveolae participate in cell survival and angiogenesis, has been recently substantiated by the identification of two novel caveol...

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Bibliographic Details
Published in:Cellular Signalling 2002-02, Vol.14 (2), p.93-98
Main Authors: Massimino, Maria Lina, Griffoni, Cristiana, Spisni, Enzo, Toni, Mattia, Tomasi, Vittorio
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Binding Sites
Caveolae - chemistry
Caveolae - physiology
Caveolin
Caveolin 1
Caveolins - metabolism
Cell Survival
Cytochrome P-450 Enzyme System - chemistry
Cytochrome P-450 Enzyme System - physiology
Humans
Intramolecular Oxidoreductases - chemistry
Intramolecular Oxidoreductases - physiology
Mice
Neovascularization, Physiologic
Prion protein
Prostacyclin synthase
Protein Structure, Tertiary
PrPC Proteins - chemistry
PrPC Proteins - physiology
Signal Transduction
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Summary:Caveolae, the flask-shaped membrane invaginations abundant in endothelial cells, have acquired a prominent role in signal transduction. Evidence, that events occurring in caveolae participate in cell survival and angiogenesis, has been recently substantiated by the identification of two novel caveolar constituents: prostacyclin synthase (PGIS) and the cellular form of prion protein (PrP c). We have shown that PGIS, previously described as an endoplasmic reticulum component, is bound to caveolin-1 (cav-1) and localized in caveolae in human endothelial cells. By generating prostacyclin, PGIS is involved in angiogenesis. Previous observations regarding the localization of PrP c in caveolae-like membrane domains (CLDs) have been recently confirmed and extended. It has been demonstrated that PrP c is bound to cav-1 and, by recruiting Fyn kinase, can participate in signal transduction events connected to cell survival and differentiation. The new entries of PGIS and PrP c in caveolar components place caveolae and CLDs at the centre of a network, where cells decide whether to proliferate or differentiate and whether to survive or to suicide by apoptosis.
ISSN:0898-6568
1873-3913
DOI:10.1016/S0898-6568(01)00232-7