Interrelation between compensation of carbohydrate metabolism and severity of manifestations of oxidative stress in type II diabetes mellitus

Glycosylation end-products formed during diabetes mellitus promoted atherogenic oxidative modification of low-density lipoproteins. We evaluated the effects of compensation of carbohydrate metabolism and therapy with antioxidant probucol on parameters of free radical oxidation in patients with type...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-08, Vol.136 (2), p.132-134
Main Authors: Nedosugova, L V, Lankin, V Z, Balabolkin, M I, Konovalova, G G, Lisina, M O, Antonova, K V, Tikhaze, A K, Belenkov, Yu N
Format: Article
Language:English
Subjects:
Aged
Antioxidants - therapeutic use
Carbohydrate Metabolism
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - metabolism
Female
Glycated Hemoglobin A - metabolism
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - therapeutic use
Lipid Peroxidation
Lipoproteins, LDL - blood
Male
Malondialdehyde - blood
Middle Aged
Oxidation-Reduction
Oxidative Stress
Probucol - therapeutic use
Reactive Oxygen Species - metabolism
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Summary:Glycosylation end-products formed during diabetes mellitus promoted atherogenic oxidative modification of low-density lipoproteins. We evaluated the effects of compensation of carbohydrate metabolism and therapy with antioxidant probucol on parameters of free radical oxidation in patients with type II diabetes mellitus. Compensation of carbohydrate metabolism reduced manifestations of oxidative stress, which was manifested in accelerated enzymatic utilization of reactive oxygen species and lipid peroxides and decreased content of free radical oxidation products in low-density lipoproteins. In patients with type II diabetes mellitus combination therapy with antioxidant probucol decreased the severity of oxidative stress and stabilized carbohydrate metabolism without increasing the dose of hypoglycemic preparations.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1026302520288