Interrelation between compensation of carbohydrate metabolism and severity of manifestations of oxidative stress in type II diabetes mellitus

Glycosylation end-products formed during diabetes mellitus promoted atherogenic oxidative modification of low-density lipoproteins. We evaluated the effects of compensation of carbohydrate metabolism and therapy with antioxidant probucol on parameters of free radical oxidation in patients with type...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-08, Vol.136 (2), p.132-134
Main Authors: Nedosugova, L V, Lankin, V Z, Balabolkin, M I, Konovalova, G G, Lisina, M O, Antonova, K V, Tikhaze, A K, Belenkov, Yu N
Format: Article
Language:English
Subjects:
Aged
Antioxidants - therapeutic use
Carbohydrate Metabolism
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - metabolism
Female
Glycated Hemoglobin A - metabolism
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - therapeutic use
Lipid Peroxidation
Lipoproteins, LDL - blood
Male
Malondialdehyde - blood
Middle Aged
Oxidation-Reduction
Oxidative Stress
Probucol - therapeutic use
Reactive Oxygen Species - metabolism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 134
container_issue 2
container_start_page 132
container_title Bulletin of experimental biology and medicine
container_volume 136
creator Nedosugova, L V
Lankin, V Z
Balabolkin, M I
Konovalova, G G
Lisina, M O
Antonova, K V
Tikhaze, A K
Belenkov, Yu N
description Glycosylation end-products formed during diabetes mellitus promoted atherogenic oxidative modification of low-density lipoproteins. We evaluated the effects of compensation of carbohydrate metabolism and therapy with antioxidant probucol on parameters of free radical oxidation in patients with type II diabetes mellitus. Compensation of carbohydrate metabolism reduced manifestations of oxidative stress, which was manifested in accelerated enzymatic utilization of reactive oxygen species and lipid peroxides and decreased content of free radical oxidation products in low-density lipoproteins. In patients with type II diabetes mellitus combination therapy with antioxidant probucol decreased the severity of oxidative stress and stabilized carbohydrate metabolism without increasing the dose of hypoglycemic preparations.
doi_str_mv 10.1023/A:1026302520288
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_71397324</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>436458541</sourcerecordid><originalsourceid>FETCH-LOGICAL-p234t-1f4a3de72cda306f7d14b20a1f5afc11e7a08068493ca8ea9a9454c99b2de8b03</originalsourceid><addsrcrecordid>eNpdkE9P3DAQxa2qqGxpz9yQ1UNvAf9LYveGVrRdCYkLPUeTeKIaJXZqO8B-CL4z3gIXTqP39Js3T0PIKWfnnAl5cfmjjEYyUQsmtP5ANrxuZaWF4B_JhjHWVkprfUw-p3R3kKzhn8gxV43kyvANedr5jDHiBNkFT3vMD4ieDmFe0KcXM4x0gNiHv3sbISOdMUMfJpdmCt7ShPcYXd4fuBm8GzHl_4vp4IRHZ4u6R5pyxJSo8zTvF6S7HbUOykFMJXGaXF7TF3I0wpTw6-s8IX9-Xt1uf1fXN79228vrahFS5YqPCqTFVgwWJGvG1nLVCwZ8rGEcOMcWmGaNVkYOoBEMGFWrwZheWNQ9kyfk-0vuEsO_tfTtZpeGUgI8hjV1LZemlUIV8Ns78C6s0ZduneBSNcKYukBnr9Daz2i7JboZ4r57-7J8Bq5mgjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213462995</pqid></control><display><type>article</type><title>Interrelation between compensation of carbohydrate metabolism and severity of manifestations of oxidative stress in type II diabetes mellitus</title><source>Springer Nature</source><creator>Nedosugova, L V ; Lankin, V Z ; Balabolkin, M I ; Konovalova, G G ; Lisina, M O ; Antonova, K V ; Tikhaze, A K ; Belenkov, Yu N</creator><creatorcontrib>Nedosugova, L V ; Lankin, V Z ; Balabolkin, M I ; Konovalova, G G ; Lisina, M O ; Antonova, K V ; Tikhaze, A K ; Belenkov, Yu N</creatorcontrib><description>Glycosylation end-products formed during diabetes mellitus promoted atherogenic oxidative modification of low-density lipoproteins. We evaluated the effects of compensation of carbohydrate metabolism and therapy with antioxidant probucol on parameters of free radical oxidation in patients with type II diabetes mellitus. Compensation of carbohydrate metabolism reduced manifestations of oxidative stress, which was manifested in accelerated enzymatic utilization of reactive oxygen species and lipid peroxides and decreased content of free radical oxidation products in low-density lipoproteins. In patients with type II diabetes mellitus combination therapy with antioxidant probucol decreased the severity of oxidative stress and stabilized carbohydrate metabolism without increasing the dose of hypoglycemic preparations.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1023/A:1026302520288</identifier><identifier>PMID: 14631491</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Aged ; Antioxidants - therapeutic use ; Carbohydrate Metabolism ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - metabolism ; Female ; Glycated Hemoglobin A - metabolism ; Humans ; Hypoglycemic Agents - administration &amp; dosage ; Hypoglycemic Agents - therapeutic use ; Lipid Peroxidation ; Lipoproteins, LDL - blood ; Male ; Malondialdehyde - blood ; Middle Aged ; Oxidation-Reduction ; Oxidative Stress ; Probucol - therapeutic use ; Reactive Oxygen Species - metabolism</subject><ispartof>Bulletin of experimental biology and medicine, 2003-08, Vol.136 (2), p.132-134</ispartof><rights>Copyright (c) 2003 Plenum Publishing Corporation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14631491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nedosugova, L V</creatorcontrib><creatorcontrib>Lankin, V Z</creatorcontrib><creatorcontrib>Balabolkin, M I</creatorcontrib><creatorcontrib>Konovalova, G G</creatorcontrib><creatorcontrib>Lisina, M O</creatorcontrib><creatorcontrib>Antonova, K V</creatorcontrib><creatorcontrib>Tikhaze, A K</creatorcontrib><creatorcontrib>Belenkov, Yu N</creatorcontrib><title>Interrelation between compensation of carbohydrate metabolism and severity of manifestations of oxidative stress in type II diabetes mellitus</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>Glycosylation end-products formed during diabetes mellitus promoted atherogenic oxidative modification of low-density lipoproteins. We evaluated the effects of compensation of carbohydrate metabolism and therapy with antioxidant probucol on parameters of free radical oxidation in patients with type II diabetes mellitus. Compensation of carbohydrate metabolism reduced manifestations of oxidative stress, which was manifested in accelerated enzymatic utilization of reactive oxygen species and lipid peroxides and decreased content of free radical oxidation products in low-density lipoproteins. In patients with type II diabetes mellitus combination therapy with antioxidant probucol decreased the severity of oxidative stress and stabilized carbohydrate metabolism without increasing the dose of hypoglycemic preparations.</description><subject>Aged</subject><subject>Antioxidants - therapeutic use</subject><subject>Carbohydrate Metabolism</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Female</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Hypoglycemic Agents - administration &amp; dosage</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Lipid Peroxidation</subject><subject>Lipoproteins, LDL - blood</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Middle Aged</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Probucol - therapeutic use</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpdkE9P3DAQxa2qqGxpz9yQ1UNvAf9LYveGVrRdCYkLPUeTeKIaJXZqO8B-CL4z3gIXTqP39Js3T0PIKWfnnAl5cfmjjEYyUQsmtP5ANrxuZaWF4B_JhjHWVkprfUw-p3R3kKzhn8gxV43kyvANedr5jDHiBNkFT3vMD4ieDmFe0KcXM4x0gNiHv3sbISOdMUMfJpdmCt7ShPcYXd4fuBm8GzHl_4vp4IRHZ4u6R5pyxJSo8zTvF6S7HbUOykFMJXGaXF7TF3I0wpTw6-s8IX9-Xt1uf1fXN79228vrahFS5YqPCqTFVgwWJGvG1nLVCwZ8rGEcOMcWmGaNVkYOoBEMGFWrwZheWNQ9kyfk-0vuEsO_tfTtZpeGUgI8hjV1LZemlUIV8Ns78C6s0ZduneBSNcKYukBnr9Daz2i7JboZ4r57-7J8Bq5mgjw</recordid><startdate>200308</startdate><enddate>200308</enddate><creator>Nedosugova, L V</creator><creator>Lankin, V Z</creator><creator>Balabolkin, M I</creator><creator>Konovalova, G G</creator><creator>Lisina, M O</creator><creator>Antonova, K V</creator><creator>Tikhaze, A K</creator><creator>Belenkov, Yu N</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200308</creationdate><title>Interrelation between compensation of carbohydrate metabolism and severity of manifestations of oxidative stress in type II diabetes mellitus</title><author>Nedosugova, L V ; Lankin, V Z ; Balabolkin, M I ; Konovalova, G G ; Lisina, M O ; Antonova, K V ; Tikhaze, A K ; Belenkov, Yu N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p234t-1f4a3de72cda306f7d14b20a1f5afc11e7a08068493ca8ea9a9454c99b2de8b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Antioxidants - therapeutic use</topic><topic>Carbohydrate Metabolism</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Female</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Hypoglycemic Agents - administration &amp; dosage</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Lipid Peroxidation</topic><topic>Lipoproteins, LDL - blood</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Middle Aged</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Probucol - therapeutic use</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nedosugova, L V</creatorcontrib><creatorcontrib>Lankin, V Z</creatorcontrib><creatorcontrib>Balabolkin, M I</creatorcontrib><creatorcontrib>Konovalova, G G</creatorcontrib><creatorcontrib>Lisina, M O</creatorcontrib><creatorcontrib>Antonova, K V</creatorcontrib><creatorcontrib>Tikhaze, A K</creatorcontrib><creatorcontrib>Belenkov, Yu N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nedosugova, L V</au><au>Lankin, V Z</au><au>Balabolkin, M I</au><au>Konovalova, G G</au><au>Lisina, M O</au><au>Antonova, K V</au><au>Tikhaze, A K</au><au>Belenkov, Yu N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interrelation between compensation of carbohydrate metabolism and severity of manifestations of oxidative stress in type II diabetes mellitus</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><addtitle>Bull Exp Biol Med</addtitle><date>2003-08</date><risdate>2003</risdate><volume>136</volume><issue>2</issue><spage>132</spage><epage>134</epage><pages>132-134</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>Glycosylation end-products formed during diabetes mellitus promoted atherogenic oxidative modification of low-density lipoproteins. We evaluated the effects of compensation of carbohydrate metabolism and therapy with antioxidant probucol on parameters of free radical oxidation in patients with type II diabetes mellitus. Compensation of carbohydrate metabolism reduced manifestations of oxidative stress, which was manifested in accelerated enzymatic utilization of reactive oxygen species and lipid peroxides and decreased content of free radical oxidation products in low-density lipoproteins. In patients with type II diabetes mellitus combination therapy with antioxidant probucol decreased the severity of oxidative stress and stabilized carbohydrate metabolism without increasing the dose of hypoglycemic preparations.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>14631491</pmid><doi>10.1023/A:1026302520288</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0007-4888
ispartof Bulletin of experimental biology and medicine, 2003-08, Vol.136 (2), p.132-134
issn 0007-4888
1573-8221
language eng
recordid cdi_proquest_miscellaneous_71397324
source Springer Nature
subjects Aged
Antioxidants - therapeutic use
Carbohydrate Metabolism
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - metabolism
Female
Glycated Hemoglobin A - metabolism
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - therapeutic use
Lipid Peroxidation
Lipoproteins, LDL - blood
Male
Malondialdehyde - blood
Middle Aged
Oxidation-Reduction
Oxidative Stress
Probucol - therapeutic use
Reactive Oxygen Species - metabolism
title Interrelation between compensation of carbohydrate metabolism and severity of manifestations of oxidative stress in type II diabetes mellitus
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T20%3A42%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interrelation%20between%20compensation%20of%20carbohydrate%20metabolism%20and%20severity%20of%20manifestations%20of%20oxidative%20stress%20in%20type%20II%20diabetes%20mellitus&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Nedosugova,%20L%20V&rft.date=2003-08&rft.volume=136&rft.issue=2&rft.spage=132&rft.epage=134&rft.pages=132-134&rft.issn=0007-4888&rft.eissn=1573-8221&rft.coden=BEXBAN&rft_id=info:doi/10.1023/A:1026302520288&rft_dat=%3Cproquest_pubme%3E436458541%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p234t-1f4a3de72cda306f7d14b20a1f5afc11e7a08068493ca8ea9a9454c99b2de8b03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=213462995&rft_id=info:pmid/14631491&rfr_iscdi=true