When might hemispheric favouring of epileptiform discharges begin?

Purpose: EEG studies based on adult populations report interictal epileptiform discharges (EDS) favour the left hemisphere. It is not clear when favouring becomes apparent as similar paediatric studies have not been performed. Methods: The authors reviewed 1579 paediatric EEG interpretations for evi...

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Published in:Seizure (London, England) England), 2003-12, Vol.12 (8), p.595-598
Main Authors: DOHERTY, M.J, SIMON, E, DE MENEZES, M.S, KURATANI, J.D, SANETO, R.P, HOLMES, M.D, FARRELL, D.F, WATSON, N.F, DODRILL, C.B, MILLER, J.W
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Chi-Square Distribution
Child
Child, Preschool
developmental
electroencephalogram
Electroencephalography - methods
Electroencephalography - statistics & numerical data
epilepsy
Epilepsy - physiopathology
Humans
Infant
Infant, Newborn
paediatric
Retrospective Studies
Telencephalon - physiopathology
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Summary:Purpose: EEG studies based on adult populations report interictal epileptiform discharges (EDS) favour the left hemisphere. It is not clear when favouring becomes apparent as similar paediatric studies have not been performed. Methods: The authors reviewed 1579 paediatric EEG interpretations for evidence of hemispheric favouring of focal epileptiform discharges. Analysis focused on first-time EEG results. Results: Right hemispheric favouring of interictal epileptiform discharges occurs in childhood, it remits around 5 years of age whereupon left-sided favouring occurs more frequently ( P=0.004, Fisher’s Exact). Conclusion: Hemispheric vulnerabilities to interictal focal epileptiform activity may display discrete age-related favouring. These findings are discussed in context of normal hemispheric maturation.
ISSN:1059-1311
1532-2688
DOI:10.1016/S1059-1311(03)00107-9