Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties

The different dialkyl and diaryl diselenides with carbamoyl and sulfamoyl moieties 2, 3, 5 and other substituents in the ortho position of benzene ring 4, 7, 8 as well as derivatives of 1,2,4-benzoselenadiazine ( 6) were designed as antiviral and antimicrobial agents and synthesized. Some of them, p...

Full description

Saved in:
Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 2003-12, Vol.58 (12), p.1235-1242
Main Authors: Wójtowicz, H, Chojnacka, M, Młochowski, J, Palus, J, Syper, L, Hudecova, D, Uher, M, Piasecki, E, Rybka, M
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacology
Bacteriocides
Biological and medical sciences
Cell Line, Tumor
Chemical control
Control
Diselenides
Ebselen
Fundamental and applied biological sciences. Psychology
Fungal plant pathogens
Fungicides
Humans
Medical sciences
Mice
Microbial Sensitivity Tests - methods
Organoselenium Compounds - chemical synthesis
Organoselenium Compounds - pharmacology
Pharmacology. Drug treatments
Phytopathology. Animal pests. Plant and forest protection
Virucides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The different dialkyl and diaryl diselenides with carbamoyl and sulfamoyl moieties 2, 3, 5 and other substituents in the ortho position of benzene ring 4, 7, 8 as well as derivatives of 1,2,4-benzoselenadiazine ( 6) were designed as antiviral and antimicrobial agents and synthesized. Some of them, particularly 8a and 8b, were found in the antiviral assay in vitro to be strong inhibitors of cytopathic activity encephalomyocarditis virus (EMCV). The compound 4a and 8a were found to have a broad spectrum of acivity against bacteria, yeasts and pathogenic fungi in vitro.
ISSN:0014-827X
1879-0569
DOI:10.1016/j.farmac.2003.08.003