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Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties
The different dialkyl and diaryl diselenides with carbamoyl and sulfamoyl moieties 2, 3, 5 and other substituents in the ortho position of benzene ring 4, 7, 8 as well as derivatives of 1,2,4-benzoselenadiazine ( 6) were designed as antiviral and antimicrobial agents and synthesized. Some of them, p...
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| Published in: | Farmaco (Società chimica italiana : 1989) 2003-12, Vol.58 (12), p.1235-1242 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c303t-ef8fc45c8eab2f72011028e2bf6088acbb5ee24e2bfcd4a4fe29f1f423d33c883 |
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| cites | cdi_FETCH-LOGICAL-c303t-ef8fc45c8eab2f72011028e2bf6088acbb5ee24e2bfcd4a4fe29f1f423d33c883 |
| container_end_page | 1242 |
| container_issue | 12 |
| container_start_page | 1235 |
| container_title | Farmaco (Società chimica italiana : 1989) |
| container_volume | 58 |
| creator | Wójtowicz, H Chojnacka, M Młochowski, J Palus, J Syper, L Hudecova, D Uher, M Piasecki, E Rybka, M |
| description | The different dialkyl and diaryl diselenides with carbamoyl and sulfamoyl moieties
2,
3,
5 and other substituents in the
ortho position of benzene ring
4,
7,
8 as well as derivatives of 1,2,4-benzoselenadiazine (
6) were designed as antiviral and antimicrobial agents and synthesized. Some of them, particularly
8a and
8b, were found in the antiviral assay in vitro to be strong inhibitors of cytopathic activity encephalomyocarditis virus (EMCV). The compound
4a and
8a were found to have a broad spectrum of acivity against bacteria, yeasts and pathogenic fungi in vitro. |
| doi_str_mv | 10.1016/j.farmac.2003.08.003 |
| format | article |
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2,
3,
5 and other substituents in the
ortho position of benzene ring
4,
7,
8 as well as derivatives of 1,2,4-benzoselenadiazine (
6) were designed as antiviral and antimicrobial agents and synthesized. Some of them, particularly
8a and
8b, were found in the antiviral assay in vitro to be strong inhibitors of cytopathic activity encephalomyocarditis virus (EMCV). The compound
4a and
8a were found to have a broad spectrum of acivity against bacteria, yeasts and pathogenic fungi in vitro.</description><identifier>ISSN: 0014-827X</identifier><identifier>EISSN: 1879-0569</identifier><identifier>DOI: 10.1016/j.farmac.2003.08.003</identifier><identifier>PMID: 14630233</identifier><language>eng</language><publisher>Lausanne: Elsevier SAS</publisher><subject>Animals ; Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Antiviral Agents - chemical synthesis ; Antiviral Agents - pharmacology ; Bacteriocides ; Biological and medical sciences ; Cell Line, Tumor ; Chemical control ; Control ; Diselenides ; Ebselen ; Fundamental and applied biological sciences. Psychology ; Fungal plant pathogens ; Fungicides ; Humans ; Medical sciences ; Mice ; Microbial Sensitivity Tests - methods ; Organoselenium Compounds - chemical synthesis ; Organoselenium Compounds - pharmacology ; Pharmacology. Drug treatments ; Phytopathology. Animal pests. Plant and forest protection ; Virucides</subject><ispartof>Farmaco (Società chimica italiana : 1989), 2003-12, Vol.58 (12), p.1235-1242</ispartof><rights>2003 Éditions scientifiques et médicales Elsevier SAS</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-ef8fc45c8eab2f72011028e2bf6088acbb5ee24e2bfcd4a4fe29f1f423d33c883</citedby><cites>FETCH-LOGICAL-c303t-ef8fc45c8eab2f72011028e2bf6088acbb5ee24e2bfcd4a4fe29f1f423d33c883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15338442$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14630233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wójtowicz, H</creatorcontrib><creatorcontrib>Chojnacka, M</creatorcontrib><creatorcontrib>Młochowski, J</creatorcontrib><creatorcontrib>Palus, J</creatorcontrib><creatorcontrib>Syper, L</creatorcontrib><creatorcontrib>Hudecova, D</creatorcontrib><creatorcontrib>Uher, M</creatorcontrib><creatorcontrib>Piasecki, E</creatorcontrib><creatorcontrib>Rybka, M</creatorcontrib><title>Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties</title><title>Farmaco (Società chimica italiana : 1989)</title><addtitle>Farmaco</addtitle><description>The different dialkyl and diaryl diselenides with carbamoyl and sulfamoyl moieties
2,
3,
5 and other substituents in the
ortho position of benzene ring
4,
7,
8 as well as derivatives of 1,2,4-benzoselenadiazine (
6) were designed as antiviral and antimicrobial agents and synthesized. Some of them, particularly
8a and
8b, were found in the antiviral assay in vitro to be strong inhibitors of cytopathic activity encephalomyocarditis virus (EMCV). The compound
4a and
8a were found to have a broad spectrum of acivity against bacteria, yeasts and pathogenic fungi in vitro.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - chemical synthesis</subject><subject>Antiviral Agents - pharmacology</subject><subject>Bacteriocides</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Chemical control</subject><subject>Control</subject><subject>Diselenides</subject><subject>Ebselen</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungal plant pathogens</subject><subject>Fungicides</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Organoselenium Compounds - chemical synthesis</subject><subject>Organoselenium Compounds - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytopathology. Animal pests. Plant and forest protection</subject><subject>Virucides</subject><issn>0014-827X</issn><issn>1879-0569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp9kEtrGzEQx0VpSFw336AUX5rbbvTyrpxDIIQmKRhySaE3odWOmnF2ta5mHXA_feR6IbeCYB76zevP2BfBS8FFdbkpg0u986XkXJXclNl8YDNh6lXBl9XqI5txLnRhZP3rjH0i2uSwrqv6lJ0JXSkulZoxvNtFP-IQXYd_oV247mXfLVzMXspOiwQdRGyBFi6_OGKPPg0NuonKmVdMh-g3xJGuFrSP4zMQ0r__bRq2kEYE-sxOgusIzic7Zz_vvj_dPhTrx_sftzfrwiuuxgKCCV4vvQHXyFBLLgSXBmQTKm6M802zBJD6kPCtdjqAXAURtFStUt4YNWcXx7559J8d0Gh7JA9d5yIMO7K1UKu6qkQG9RHM9xAlCHabsM9nW8HtQWK7sUeJ7UFiy43NJpd9nfrvmh7a96JJ0wx8mwBH3nUhueiR3rmlUkbnfefs-shBVuMVIVnyCNFDiwn8aNsB_7_JGyO-nq4</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>Wójtowicz, H</creator><creator>Chojnacka, M</creator><creator>Młochowski, J</creator><creator>Palus, J</creator><creator>Syper, L</creator><creator>Hudecova, D</creator><creator>Uher, M</creator><creator>Piasecki, E</creator><creator>Rybka, M</creator><general>Elsevier SAS</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200312</creationdate><title>Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties</title><author>Wójtowicz, H ; Chojnacka, M ; Młochowski, J ; Palus, J ; Syper, L ; Hudecova, D ; Uher, M ; Piasecki, E ; Rybka, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-ef8fc45c8eab2f72011028e2bf6088acbb5ee24e2bfcd4a4fe29f1f423d33c883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - chemical synthesis</topic><topic>Antiviral Agents - pharmacology</topic><topic>Bacteriocides</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Chemical control</topic><topic>Control</topic><topic>Diselenides</topic><topic>Ebselen</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungal plant pathogens</topic><topic>Fungicides</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests - methods</topic><topic>Organoselenium Compounds - chemical synthesis</topic><topic>Organoselenium Compounds - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytopathology. Animal pests. Plant and forest protection</topic><topic>Virucides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wójtowicz, H</creatorcontrib><creatorcontrib>Chojnacka, M</creatorcontrib><creatorcontrib>Młochowski, J</creatorcontrib><creatorcontrib>Palus, J</creatorcontrib><creatorcontrib>Syper, L</creatorcontrib><creatorcontrib>Hudecova, D</creatorcontrib><creatorcontrib>Uher, M</creatorcontrib><creatorcontrib>Piasecki, E</creatorcontrib><creatorcontrib>Rybka, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Farmaco (Società chimica italiana : 1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wójtowicz, H</au><au>Chojnacka, M</au><au>Młochowski, J</au><au>Palus, J</au><au>Syper, L</au><au>Hudecova, D</au><au>Uher, M</au><au>Piasecki, E</au><au>Rybka, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties</atitle><jtitle>Farmaco (Società chimica italiana : 1989)</jtitle><addtitle>Farmaco</addtitle><date>2003-12</date><risdate>2003</risdate><volume>58</volume><issue>12</issue><spage>1235</spage><epage>1242</epage><pages>1235-1242</pages><issn>0014-827X</issn><eissn>1879-0569</eissn><abstract>The different dialkyl and diaryl diselenides with carbamoyl and sulfamoyl moieties
2,
3,
5 and other substituents in the
ortho position of benzene ring
4,
7,
8 as well as derivatives of 1,2,4-benzoselenadiazine (
6) were designed as antiviral and antimicrobial agents and synthesized. Some of them, particularly
8a and
8b, were found in the antiviral assay in vitro to be strong inhibitors of cytopathic activity encephalomyocarditis virus (EMCV). The compound
4a and
8a were found to have a broad spectrum of acivity against bacteria, yeasts and pathogenic fungi in vitro.</abstract><cop>Lausanne</cop><pub>Elsevier SAS</pub><pmid>14630233</pmid><doi>10.1016/j.farmac.2003.08.003</doi><tpages>8</tpages></addata></record> |
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| ispartof | Farmaco (Società chimica italiana : 1989), 2003-12, Vol.58 (12), p.1235-1242 |
| issn | 0014-827X 1879-0569 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71397661 |
| source | Elsevier |
| subjects | Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Bacteriocides Biological and medical sciences Cell Line, Tumor Chemical control Control Diselenides Ebselen Fundamental and applied biological sciences. Psychology Fungal plant pathogens Fungicides Humans Medical sciences Mice Microbial Sensitivity Tests - methods Organoselenium Compounds - chemical synthesis Organoselenium Compounds - pharmacology Pharmacology. Drug treatments Phytopathology. Animal pests. Plant and forest protection Virucides |
| title | Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties |
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