Comparative analysis of NK/T-cell lymphoma and peripheral T-cell lymphoma in Korea: Clinicopathological correlations and analysis of EBV strain type and 30-bp deletion variant LMP1

Natural killer/T‐cell lymphoma (NKTL) and peripheral T‐cell lymphomas (PTCL) are prevalent in the Asian population and exhibit a high association with the Epstein–Barr virus (EBV). Moreover, differentiation of these two groups is often difficult and problematic. We investigated 35 cases of NKTL (22...

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Bibliographic Details
Published in:Pathology international 2003-11, Vol.53 (11), p.735-743
Main Authors: Kim, Ji Eun, Kim, Young A., Jeon, Yoon Kyung, Park, Sung Shin, Heo, Dae Seog, Kim, Chul Woo
Format: Article
Language:English
Subjects:
Adult
Aged
Cell Line
Cell Line, Tumor
Child
DNA, Viral - classification
DNA, Viral - genetics
Epstein-Barr virus
Epstein-Barr Virus Infections - pathology
Epstein-Barr Virus Infections - virology
Female
Follow-Up Studies
Gene Deletion
Herpesvirus 4, Human - genetics
Humans
Immunophenotyping
In Situ Hybridization
Killer Cells, Natural - pathology
Korea
latent membrane protein 1
Lymphoma, T-Cell - immunology
Lymphoma, T-Cell - pathology
Lymphoma, T-Cell - virology
Lymphoma, T-Cell, Peripheral - immunology
Lymphoma, T-Cell, Peripheral - pathology
Lymphoma, T-Cell, Peripheral - virology
Male
Middle Aged
natural killer
Neoplasm Staging
peripheral T-cell lymphoma
Polymerase Chain Reaction
Survival Analysis
T-cell lymphoma
Viral Matrix Proteins - genetics
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Summary:Natural killer/T‐cell lymphoma (NKTL) and peripheral T‐cell lymphomas (PTCL) are prevalent in the Asian population and exhibit a high association with the Epstein–Barr virus (EBV). Moreover, differentiation of these two groups is often difficult and problematic. We investigated 35 cases of NKTL (22 nasal cases and 13 extranasal cases) and 30 cases of PTCL in terms of their clinical features, immunohistology, EBV positivity, EBV strain‐type polymorphism and latent membrane protein 1 (LMP1) deletion variant distribution. Eighteen cases (82%) of nasal NKTL and seven (54%) of extranasal NKTL showed EBV positivity by EBV in situ hybridization. Fifteen cases (50%) of PTCL revealed EBV positivity. EBV strain type A was predominant in NKTL (18:5), and EBV strain types A and B were distributed evenly in PTCL (6:6). EBV‐positive patients had significantly shorter survival than EBV‐negative patients (P 
ISSN:1320-5463
1440-1827
DOI:10.1046/j.1320-5463.2003.01552.x