Dehydroepiandrosterone replacement in healthy men with age-related decline of DHEA-S: effects on fat distribution, insulin sensitivity and lipid metabolism

Many animal and human studies show that supraphysiological doses of dehydroepiandrosterone (DHEA) can influence body composition and carbohydrate and lipid metabolism. Most studies have concentrated on women and have not been randomized, thus creating controversial results. With this in mind, we des...

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Bibliographic Details
Published in:The aging male 2003-09, Vol.6 (3), p.151-156
Main Authors: Jedrzejuk, D, Medras, M, Milewicz, A, Demissie, M
Format: Article
Language:English
Subjects:
Adipose Tissue - drug effects
Age Factors
Aging
Body Composition - drug effects
Body fat
Body Mass Index
Cholesterol - blood
Cross-Over Studies
Dehydroepiandrosterone Sulfate - administration & dosage
Dehydroepiandrosterone Sulfate - metabolism
Dehydroepiandrosterone Sulfate - pharmacology
Double-Blind Method
Estradiol - blood
Hormone Replacement Therapy
Humans
Insulin
Insulin Resistance
Lipids - blood
Male
Males
Metabolism
Middle Aged
Placebos
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Summary:Many animal and human studies show that supraphysiological doses of dehydroepiandrosterone (DHEA) can influence body composition and carbohydrate and lipid metabolism. Most studies have concentrated on women and have not been randomized, thus creating controversial results. With this in mind, we designed a cross-over double-blind placebo-controlled study of 12 men aged 59.0 +/- 4.8 years, who received either 50 mg/24 h DHEA or placebo for 3 months to assess the influence of DHEA on the content and distribution of fat tissue and serum insulin, glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol levels, as well as testosterone, estradiol, DHEA-sulfate (S), prostate-specific antigen (PSA) concentrations and indexes of insulin sensitivity and resistance. Patients were recruited from university employees attending for periodic health checks, with normal hepatic and renal function with endogenous DHEA-S level < 1500 ng/dl. Our results did not reveal any significant changes in study parameters, apart from a statistically significant increase in DHEA-S levels after therapy with active substance.
ISSN:1368-5538
1473-0790
DOI:10.1080/713604785