Monolayer-Protected Gold Nanoparticles as a Stationary Phase for Open Tubular Gas Chromatography

The use of a thin film of monolayer-protected gold nanoparticles (MPNs) as a stationary phase for gas chromatography (GC) is reported. Deposition of a MPN film was obtained in a 2-m, 530-μm-i.d. deactivated silica capillary using gravity to force the solution containing the MPN material through the...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2003-09, Vol.75 (17), p.4558-4564
Main Authors: Gross, Gwen M, Nelson, David A, Grate, Jay W, Synovec, Robert E
Format: Article
Language:English
Subjects:
Analytical chemistry
Atoms & subatomic particles
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Gas chromatographic methods
Gases
Gold
Nanotechnology
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Summary:The use of a thin film of monolayer-protected gold nanoparticles (MPNs) as a stationary phase for gas chromatography (GC) is reported. Deposition of a MPN film was obtained in a 2-m, 530-μm-i.d. deactivated silica capillary using gravity to force the solution containing the MPN material through the capillary. By SEM analysis, the average film thickness was determined to be 60.7 nm. The retention behavior for the dodecanethiol MPN column was studied using four compound classes (alkanes, alcohols, aromatics, ketones), and retention orders were objectively compared to a commercially available column (AT-1, 100-nm film thickness). Separation of an eight-component mixture was performed using both isothermal and temperature-programming methods with the dodecanethiol MPN phase and compared to an isothermal separation with the AT-1 phase. The AT-1 phase separation had an efficiency, N, of 6200 (k‘ = 0.33) while the dodecanethiol MPN phase separation had an efficiency, N, of 5700 (k‘ = 0.21) for the same analyte, octane. The reduced plate height, h, for octane was found to be less than 1 at the optimum linear flow velocity, indicating the MPN column operated near the optimum possible performance level. Robustness of the MPN phase is also discussed with consistent performance observed over several months. Overall, MPNs appear promising as a stationary-phase material for GC and as an experimental platform to study their thermodynamic and mass-transfer properties.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac030112j