Relation of dietary fat and fiber to elevation of C-reactive protein

We examined the relation of dietary fiber, fat, and other dietary factors to levels of highly sensitive C-reactive protein (CRP) in 4,900 adult participants in the 1999 to 2000 National Health and Nutrition Examination Survey (NHANES 99-00), which was a cross-sectional study of a nationally represen...

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Bibliographic Details
Published in:The American journal of cardiology 2003-12, Vol.92 (11), p.1335-1339
Main Authors: King, Dana E, Egan, Brent M, Geesey, Mark E
Format: Article
Language:English
Subjects:
Biological and medical sciences
C-Reactive Protein - analysis
Cardiology
Cardiology. Vascular system
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Coronary heart disease
Cross-Sectional Studies
Dietary Fats - administration & dosage
Dietary fiber
Dietary Fiber - administration & dosage
Female
Heart
Humans
Male
Medical sciences
Nutrition Surveys
Oils & fats
Proteins
Regression Analysis
Risk Factors
United States - epidemiology
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Summary:We examined the relation of dietary fiber, fat, and other dietary factors to levels of highly sensitive C-reactive protein (CRP) in 4,900 adult participants in the 1999 to 2000 National Health and Nutrition Examination Survey (NHANES 99-00), which was a cross-sectional study of a nationally representative sample of noninstitutionalized United States residents. After controlling for demographic factors, body mass index, smoking, alcohol consumption, exercise, and total caloric intake, subjects in the third and fourth highest quartiles of fiber consumption had a lower risk of elevated CRP (odds ratio [OR] 0.64, 95% confidence interval [CI] 0.43 to 0.96; OR 0.58, 95% CI 0.38 to 0.88, respectively) compared with the lowest quartile. Saturated fat consumption was modestly associated with elevated CRP (third quartile: OR 1.58, 95% CI 1.02 to 2.44; fourth quartile 1.44, 95% CI 0.80 to 2.58). The findings suggest that inflammation may link dietary fiber and fat to cardiovascular disease.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2003.08.020