Thalamic Dysfunction in Juvenile Myoclonic Epilepsy: A Proton MRS Study

Purpose: To investigate neuronal dysfunction in the thalami of patients with juvenile myoclonic epilepsy (JME) by using proton magnetic resonance spectroscopy (MRS). Methods: We performed single‐voxel proton MRS over the right and the left thalami of 10 consecutive patients (five women) with JME (me...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) 2003-11, Vol.44 (11), p.1402-1405
Main Authors: Mory, Susana B., Li, Li M., Guerreiro, Carlos A. M., Cendes, Fernando
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Biological and medical sciences
Creatine - metabolism
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dominance, Cerebral - physiology
Energy Metabolism - physiology
Female
Generalized epilepsy
Humans
Image Processing, Computer-Assisted
Magnetic resonance
Magnetic Resonance Spectroscopy
Male
Medical sciences
Myoclonic Epilepsy, Juvenile - physiopathology
Neurology
Phosphocreatine - metabolism
Reference Values
Spectroscopy
Thalamic Diseases - diagnosis
Thalamic Diseases - physiopathology
Thalamic dysfunction
Thalamus - physiopathology
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Summary:Purpose: To investigate neuronal dysfunction in the thalami of patients with juvenile myoclonic epilepsy (JME) by using proton magnetic resonance spectroscopy (MRS). Methods: We performed single‐voxel proton MRS over the right and the left thalami of 10 consecutive patients (five women) with JME (mean age, 31.6 years) and 10 age‐matched healthy volunteers (five men). All patients had seizure onset in late childhood–teenage, normal neurologic examination, typical EEG of JME, and normal high‐resolution MR imaging (MRI). We determined ratios of N‐acetylaspartate (NAA) over creatine‐phosphocreatine (Cr). Values
ISSN:0013-9580
1528-1167
DOI:10.1046/j.1528-1157.2003.67702.x