Successful treatment of acquired pure red cell aplasia (PRCA) by allogeneic peripheral blood stem cell transplantation

A 37‐year‐old male was treated successfully by peripheral blood stem cell transplantation (PBSCT) from his HLA‐identical sister for refractory acquired pure red cell aplasia (PRCA). The conditioning regimen was cyclophosphamide 50 mg/kg/day for 4 days plus TBI 300 cGy in a single fraction. Absolute...

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Bibliographic Details
Published in:American journal of hematology 2003-12, Vol.74 (4), p.273-275
Main Authors: Tseng, Shih‐Bin, Lin, Sheng‐Fung, Chang, Chao‐Sung, Liu, Ta‐Chih, Hsiao, Hui‐Hua, Liu, Yi‐Chang, Tsai, Hui‐Jen, Chen, Tyen‐Po
Format: Article
Language:English
Subjects:
acquired pure red cell aplasia
Adult
Anemias. Hemoglobinopathies
autoimmune diseases
Biological and medical sciences
Disease-Free Survival
Diseases of red blood cells
Follow-Up Studies
Hematologic and hematopoietic diseases
hematopoietic stem cell transplantation
Humans
Male
Medical sciences
Peripheral Blood Stem Cell Transplantation
Red-Cell Aplasia, Pure - therapy
Salvage Therapy
Transplantation Chimera
Transplantation, Homologous
Transplantation, Isogeneic
Treatment Outcome
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Summary:A 37‐year‐old male was treated successfully by peripheral blood stem cell transplantation (PBSCT) from his HLA‐identical sister for refractory acquired pure red cell aplasia (PRCA). The conditioning regimen was cyclophosphamide 50 mg/kg/day for 4 days plus TBI 300 cGy in a single fraction. Absolute neutrophil count (ANC) >500/μl and platelet counts >20,000/μl were achieved 8 days after PBSCT without transfusion. Chimerism study on day 218 revealed full donor chimerism. The hemoglobin level was stable around 12–13 g/dl with normal leukocyte and platelet counts after PBSCT during a long follow‐up period. From this case, PBSCT should be considered for patients with refractory acquired PRCA with an HLA‐identical donor. Am. J. Hematol. 74:273–275, 2003. © 2003 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.10421