Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction

Depressed myocardial blood flow (MBF) has been reported in dilated cardiomyopathy. The aim of this study was to investigate whether MBF impairment is an independent predictor of prognosis in patients with idiopathic left ventricular (LV) dysfunction. Sixty-seven patients (52 male, mean age 52+/-12 y...

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Published in:Circulation (New York, N.Y.) N.Y.), 2002-01, Vol.105 (2), p.186-193
Main Authors: NEGLIA, Danilo, MICHELASSI, Claudio, PODDIGHE, Rosa, L'ABBATE, Antonio, PARODI, Oberdan, TRIVIERI, Maria Giovanna, SAMBUCETI, Gianmario, GIORGETTI, Assuero, PRATALI, Lorenza, GALLOPIN, Michela, SALVADORI, Piero, SORACE, Oreste, CARPEGGIANI, Clara
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology. Vascular system
Coronary Circulation
Dipyridamole
Disease Progression
Disease-Free Survival
Female
Follow-Up Studies
Heart
Heart Failure - diagnosis
Humans
Male
Medical sciences
Middle Aged
Myocarditis. Cardiomyopathies
Prognosis
Proportional Hazards Models
Prospective Studies
Regional Blood Flow
Stroke Volume
Survival Rate
Tomography, Emission-Computed
Vasodilator Agents
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - mortality
Ventricular Function, Left
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Summary:Depressed myocardial blood flow (MBF) has been reported in dilated cardiomyopathy. The aim of this study was to investigate whether MBF impairment is an independent predictor of prognosis in patients with idiopathic left ventricular (LV) dysfunction. Sixty-seven patients (52 male, mean age 52+/-12 years) with different degrees of idiopathic LV systolic dysfunction (average LV ejection fraction, 0.34+/-0.10; range, 0.07 to 0.49) were prospectively enrolled. Thirty-four subjects (51%) had no history of heart failure symptoms at enrollment (NYHA class I). All patients underwent clinical and functional evaluation and a PET study to measure absolute MBF at rest and after intravenous dipyridamole. During a mean follow-up of 45+/-37 months, 24 patients had major cardiac events, including cardiac death in 8 and development or progression of heart failure in 16 patients. Multivariate regression analysis (Cox proportional hazards model) revealed heart rate (chi(2) 11.06, P
ISSN:0009-7322
1524-4539
DOI:10.1161/hc0202.102119