Glutathione peroxidase, glutathione reductase, Cu–Zn superoxide dismutase activities, glutathione, nitric oxide, and malondialdehyde concentrations in serum of patients with chronic lymphocytic leukemia

Background: Chronic lymphocytic leukemia (CLL) is a rare neoplasm that comprises a substantial proportion of all leukemias in middle-aged persons and is the most common type among elderly persons. The major causes are not known nor is there a detailed understanding about how the elusive origin(s) ma...

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Published in:Clinica chimica acta 2003-12, Vol.338 (1), p.143-149
Main Authors: Bakan, Nuri, Taysi, Seyithan, Yilmaz, Ömer, Bakan, Ebubekir, Kuşkay, Sevinç, Uzun, Naim, Gündoğdu, Mehmet
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Female
Glutathione
Glutathione - blood
Glutathione peroxidase
Glutathione Peroxidase - blood
Glutathione Reductase - blood
Hematologic and hematopoietic diseases
Humans
Investigative techniques, diagnostic techniques (general aspects)
Leukemia, Lymphocytic, Chronic, B-Cell - blood
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Malondialdehyde
Malondialdehyde - blood
Medical sciences
Middle Aged
Nitric oxide
Nitric Oxide - blood
Superoxide dismutase
Superoxide Dismutase - blood
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Summary:Background: Chronic lymphocytic leukemia (CLL) is a rare neoplasm that comprises a substantial proportion of all leukemias in middle-aged persons and is the most common type among elderly persons. The major causes are not known nor is there a detailed understanding about how the elusive origin(s) may relate to clinical expression, basic biological mechanisms, or pathogenesis. Methods: Glutathione peroxidase (GSH-Px), glutathione reductase (GRD), Cu–Zn superoxide dismutase (Cu–Zn SOD) activities, glutathione (GSH), nitric oxide (NO ), and malondialdehyde (MDA) concentrations were measured in serum of patients with CLL and a healthy control group. Results: Serum GSH-Px, Cu–Zn SOD activities, GSH concentration were lower in patients with CLL while serum NO and MDA concentrations were higher in these patients compared with the control group. Serum GRD activity was not statistically significant in patients with CLL compared with the control. However, there was no statistically significant difference in the parameters on the basis of stages in these patients. Serum GSH concentration negatively correlated with serum MDA ( r=30.63, p
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cccn.2003.08.013