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Glutathione peroxidase, glutathione reductase, Cu–Zn superoxide dismutase activities, glutathione, nitric oxide, and malondialdehyde concentrations in serum of patients with chronic lymphocytic leukemia
Background: Chronic lymphocytic leukemia (CLL) is a rare neoplasm that comprises a substantial proportion of all leukemias in middle-aged persons and is the most common type among elderly persons. The major causes are not known nor is there a detailed understanding about how the elusive origin(s) ma...
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| Published in: | Clinica chimica acta 2003-12, Vol.338 (1), p.143-149 |
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| container_title | Clinica chimica acta |
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| creator | Bakan, Nuri Taysi, Seyithan Yilmaz, Ömer Bakan, Ebubekir Kuşkay, Sevinç Uzun, Naim Gündoğdu, Mehmet |
| description | Background: Chronic lymphocytic leukemia (CLL) is a rare neoplasm that comprises a substantial proportion of all leukemias in middle-aged persons and is the most common type among elderly persons. The major causes are not known nor is there a detailed understanding about how the elusive origin(s) may relate to clinical expression, basic biological mechanisms, or pathogenesis.
Methods: Glutathione peroxidase (GSH-Px), glutathione reductase (GRD), Cu–Zn superoxide dismutase (Cu–Zn SOD) activities, glutathione (GSH), nitric oxide (NO
), and malondialdehyde (MDA) concentrations were measured in serum of patients with CLL and a healthy control group.
Results: Serum GSH-Px, Cu–Zn SOD activities, GSH concentration were lower in patients with CLL while serum NO
and MDA concentrations were higher in these patients compared with the control group. Serum GRD activity was not statistically significant in patients with CLL compared with the control. However, there was no statistically significant difference in the parameters on the basis of stages in these patients. Serum GSH concentration negatively correlated with serum MDA (
r=30.63,
p |
| doi_str_mv | 10.1016/j.cccn.2003.08.013 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71406296</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0009898103004078</els_id><sourcerecordid>71406296</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-44d9c6219c6d0a2b73259ad532712ae40a5bba731aa536de4ca0fee7238cc7cb3</originalsourceid><addsrcrecordid>eNp9kUuOEzEQhlsIxISBC7BA3sAqCX70U2IzimBAGokNbNhYlXKFOHTbwXYPZDd3mGtxCk6CexJpYMPGj6rv_23VXxTPBV8KLurXuyUiuqXkXC15u-RCPShmom3UQpWdfFjMOOfdou1acVY8iXGXryWvxePiTJS1amTTzYpfl_2YIG2td8T2FPxPayDSnH39qx7IjJjuyqvx983tF8fieIKJGRuHceoywGSvbbIU_9HPmbMpWGR3_JyBM2yA3jtjoTe0PWQT9A7JpQApKyKz-QUK48D8hu1zLbci-2HTluE2eJe9-sOw33o8pOlM4zcaLDwtHm2gj_TstJ8Xn9-9_bR6v7j6ePlhdXG1QNXKtChL02EtRV4MB7lulKw6MJWSjZBAJYdqvYZGCYBK1YZKBL4haqRqERtcq_Pi1dF3H_z3kWLSg41IfQ-O_Bh1I_KcZVdnUB5BDD7GQBu9D3aAcNCC6ylDvdNThnrKUPNW5wyz6MXJfVwPZO4lp9Ay8PIEQEToNwEc2njPVYpXqpuM3hw5yrO4thR0xDxJJGMDYdLG2__94w8pSsJ6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71406296</pqid></control><display><type>article</type><title>Glutathione peroxidase, glutathione reductase, Cu–Zn superoxide dismutase activities, glutathione, nitric oxide, and malondialdehyde concentrations in serum of patients with chronic lymphocytic leukemia</title><source>ScienceDirect Freedom Collection</source><creator>Bakan, Nuri ; Taysi, Seyithan ; Yilmaz, Ömer ; Bakan, Ebubekir ; Kuşkay, Sevinç ; Uzun, Naim ; Gündoğdu, Mehmet</creator><creatorcontrib>Bakan, Nuri ; Taysi, Seyithan ; Yilmaz, Ömer ; Bakan, Ebubekir ; Kuşkay, Sevinç ; Uzun, Naim ; Gündoğdu, Mehmet</creatorcontrib><description>Background: Chronic lymphocytic leukemia (CLL) is a rare neoplasm that comprises a substantial proportion of all leukemias in middle-aged persons and is the most common type among elderly persons. The major causes are not known nor is there a detailed understanding about how the elusive origin(s) may relate to clinical expression, basic biological mechanisms, or pathogenesis.
Methods: Glutathione peroxidase (GSH-Px), glutathione reductase (GRD), Cu–Zn superoxide dismutase (Cu–Zn SOD) activities, glutathione (GSH), nitric oxide (NO
), and malondialdehyde (MDA) concentrations were measured in serum of patients with CLL and a healthy control group.
Results: Serum GSH-Px, Cu–Zn SOD activities, GSH concentration were lower in patients with CLL while serum NO
and MDA concentrations were higher in these patients compared with the control group. Serum GRD activity was not statistically significant in patients with CLL compared with the control. However, there was no statistically significant difference in the parameters on the basis of stages in these patients. Serum GSH concentration negatively correlated with serum MDA (
r=30.63,
p<0.05) and NO
concentrations (
r=0.72,
p<0.05) in patients with advanced stage (III+IV). However, no other correlation could be found among the parameters in healthy controls and patients with CLL
Conclusions: There is significant changes in antioxidant defense system in CLL cases, which may lead to enhanced action of oxygen radical, resulting in lipid peroxidation.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cccn.2003.08.013</identifier><identifier>PMID: 14637279</identifier><identifier>CODEN: CCATAR</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Female ; Glutathione ; Glutathione - blood ; Glutathione peroxidase ; Glutathione Peroxidase - blood ; Glutathione Reductase - blood ; Hematologic and hematopoietic diseases ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemia, Lymphocytic, Chronic, B-Cell - blood ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Malondialdehyde ; Malondialdehyde - blood ; Medical sciences ; Middle Aged ; Nitric oxide ; Nitric Oxide - blood ; Superoxide dismutase ; Superoxide Dismutase - blood</subject><ispartof>Clinica chimica acta, 2003-12, Vol.338 (1), p.143-149</ispartof><rights>2003 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-44d9c6219c6d0a2b73259ad532712ae40a5bba731aa536de4ca0fee7238cc7cb3</citedby><cites>FETCH-LOGICAL-c382t-44d9c6219c6d0a2b73259ad532712ae40a5bba731aa536de4ca0fee7238cc7cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15305393$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14637279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakan, Nuri</creatorcontrib><creatorcontrib>Taysi, Seyithan</creatorcontrib><creatorcontrib>Yilmaz, Ömer</creatorcontrib><creatorcontrib>Bakan, Ebubekir</creatorcontrib><creatorcontrib>Kuşkay, Sevinç</creatorcontrib><creatorcontrib>Uzun, Naim</creatorcontrib><creatorcontrib>Gündoğdu, Mehmet</creatorcontrib><title>Glutathione peroxidase, glutathione reductase, Cu–Zn superoxide dismutase activities, glutathione, nitric oxide, and malondialdehyde concentrations in serum of patients with chronic lymphocytic leukemia</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Background: Chronic lymphocytic leukemia (CLL) is a rare neoplasm that comprises a substantial proportion of all leukemias in middle-aged persons and is the most common type among elderly persons. The major causes are not known nor is there a detailed understanding about how the elusive origin(s) may relate to clinical expression, basic biological mechanisms, or pathogenesis.
Methods: Glutathione peroxidase (GSH-Px), glutathione reductase (GRD), Cu–Zn superoxide dismutase (Cu–Zn SOD) activities, glutathione (GSH), nitric oxide (NO
), and malondialdehyde (MDA) concentrations were measured in serum of patients with CLL and a healthy control group.
Results: Serum GSH-Px, Cu–Zn SOD activities, GSH concentration were lower in patients with CLL while serum NO
and MDA concentrations were higher in these patients compared with the control group. Serum GRD activity was not statistically significant in patients with CLL compared with the control. However, there was no statistically significant difference in the parameters on the basis of stages in these patients. Serum GSH concentration negatively correlated with serum MDA (
r=30.63,
p<0.05) and NO
concentrations (
r=0.72,
p<0.05) in patients with advanced stage (III+IV). However, no other correlation could be found among the parameters in healthy controls and patients with CLL
Conclusions: There is significant changes in antioxidant defense system in CLL cases, which may lead to enhanced action of oxygen radical, resulting in lipid peroxidation.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Glutathione</subject><subject>Glutathione - blood</subject><subject>Glutathione peroxidase</subject><subject>Glutathione Peroxidase - blood</subject><subject>Glutathione Reductase - blood</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - blood</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - blood</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp9kUuOEzEQhlsIxISBC7BA3sAqCX70U2IzimBAGokNbNhYlXKFOHTbwXYPZDd3mGtxCk6CexJpYMPGj6rv_23VXxTPBV8KLurXuyUiuqXkXC15u-RCPShmom3UQpWdfFjMOOfdou1acVY8iXGXryWvxePiTJS1amTTzYpfl_2YIG2td8T2FPxPayDSnH39qx7IjJjuyqvx983tF8fieIKJGRuHceoywGSvbbIU_9HPmbMpWGR3_JyBM2yA3jtjoTe0PWQT9A7JpQApKyKz-QUK48D8hu1zLbci-2HTluE2eJe9-sOw33o8pOlM4zcaLDwtHm2gj_TstJ8Xn9-9_bR6v7j6ePlhdXG1QNXKtChL02EtRV4MB7lulKw6MJWSjZBAJYdqvYZGCYBK1YZKBL4haqRqERtcq_Pi1dF3H_z3kWLSg41IfQ-O_Bh1I_KcZVdnUB5BDD7GQBu9D3aAcNCC6ylDvdNThnrKUPNW5wyz6MXJfVwPZO4lp9Ay8PIEQEToNwEc2njPVYpXqpuM3hw5yrO4thR0xDxJJGMDYdLG2__94w8pSsJ6</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Bakan, Nuri</creator><creator>Taysi, Seyithan</creator><creator>Yilmaz, Ömer</creator><creator>Bakan, Ebubekir</creator><creator>Kuşkay, Sevinç</creator><creator>Uzun, Naim</creator><creator>Gündoğdu, Mehmet</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Glutathione peroxidase, glutathione reductase, Cu–Zn superoxide dismutase activities, glutathione, nitric oxide, and malondialdehyde concentrations in serum of patients with chronic lymphocytic leukemia</title><author>Bakan, Nuri ; Taysi, Seyithan ; Yilmaz, Ömer ; Bakan, Ebubekir ; Kuşkay, Sevinç ; Uzun, Naim ; Gündoğdu, Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-44d9c6219c6d0a2b73259ad532712ae40a5bba731aa536de4ca0fee7238cc7cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Glutathione</topic><topic>Glutathione - blood</topic><topic>Glutathione peroxidase</topic><topic>Glutathione Peroxidase - blood</topic><topic>Glutathione Reductase - blood</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - blood</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakan, Nuri</creatorcontrib><creatorcontrib>Taysi, Seyithan</creatorcontrib><creatorcontrib>Yilmaz, Ömer</creatorcontrib><creatorcontrib>Bakan, Ebubekir</creatorcontrib><creatorcontrib>Kuşkay, Sevinç</creatorcontrib><creatorcontrib>Uzun, Naim</creatorcontrib><creatorcontrib>Gündoğdu, Mehmet</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakan, Nuri</au><au>Taysi, Seyithan</au><au>Yilmaz, Ömer</au><au>Bakan, Ebubekir</au><au>Kuşkay, Sevinç</au><au>Uzun, Naim</au><au>Gündoğdu, Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione peroxidase, glutathione reductase, Cu–Zn superoxide dismutase activities, glutathione, nitric oxide, and malondialdehyde concentrations in serum of patients with chronic lymphocytic leukemia</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>338</volume><issue>1</issue><spage>143</spage><epage>149</epage><pages>143-149</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><coden>CCATAR</coden><abstract>Background: Chronic lymphocytic leukemia (CLL) is a rare neoplasm that comprises a substantial proportion of all leukemias in middle-aged persons and is the most common type among elderly persons. The major causes are not known nor is there a detailed understanding about how the elusive origin(s) may relate to clinical expression, basic biological mechanisms, or pathogenesis.
Methods: Glutathione peroxidase (GSH-Px), glutathione reductase (GRD), Cu–Zn superoxide dismutase (Cu–Zn SOD) activities, glutathione (GSH), nitric oxide (NO
), and malondialdehyde (MDA) concentrations were measured in serum of patients with CLL and a healthy control group.
Results: Serum GSH-Px, Cu–Zn SOD activities, GSH concentration were lower in patients with CLL while serum NO
and MDA concentrations were higher in these patients compared with the control group. Serum GRD activity was not statistically significant in patients with CLL compared with the control. However, there was no statistically significant difference in the parameters on the basis of stages in these patients. Serum GSH concentration negatively correlated with serum MDA (
r=30.63,
p<0.05) and NO
concentrations (
r=0.72,
p<0.05) in patients with advanced stage (III+IV). However, no other correlation could be found among the parameters in healthy controls and patients with CLL
Conclusions: There is significant changes in antioxidant defense system in CLL cases, which may lead to enhanced action of oxygen radical, resulting in lipid peroxidation.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>14637279</pmid><doi>10.1016/j.cccn.2003.08.013</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinica chimica acta, 2003-12, Vol.338 (1), p.143-149 |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Female Glutathione Glutathione - blood Glutathione peroxidase Glutathione Peroxidase - blood Glutathione Reductase - blood Hematologic and hematopoietic diseases Humans Investigative techniques, diagnostic techniques (general aspects) Leukemia, Lymphocytic, Chronic, B-Cell - blood Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Malondialdehyde Malondialdehyde - blood Medical sciences Middle Aged Nitric oxide Nitric Oxide - blood Superoxide dismutase Superoxide Dismutase - blood |
| title | Glutathione peroxidase, glutathione reductase, Cu–Zn superoxide dismutase activities, glutathione, nitric oxide, and malondialdehyde concentrations in serum of patients with chronic lymphocytic leukemia |
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