P53 possibly upregulates the expression of CD58 (LFA-3) and CD59 (MIRL)

P53 is an oncosuppressor protein which acts via transcriptional and non-transcriptional mechanisms. The transcriptional function of p53 is mediated by specific responsive elements (RE). In the present study we found one perfect p53 RE located in the first intron of the gene encoding for CD58 (lympho...

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Bibliographic Details
Published in:Medical hypotheses 2002-02, Vol.58 (2), p.136-140
Main Authors: Sampaziotis, F., Kokotas, S., Gorgoulis, V.G.
Format: Article
Language:English
Subjects:
Base Sequence
Binding Sites - genetics
CD58 Antigens - genetics
CD59 Antigens - genetics
DNA - genetics
Humans
Introns
Killer Cells, Natural - immunology
Models, Biological
Promoter Regions, Genetic
T-Lymphocytes - immunology
Tumor Suppressor Protein p53 - physiology
Up-Regulation
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Summary:P53 is an oncosuppressor protein which acts via transcriptional and non-transcriptional mechanisms. The transcriptional function of p53 is mediated by specific responsive elements (RE). In the present study we found one perfect p53 RE located in the first intron of the gene encoding for CD58 (lymphocyte function Antigen-3/LFA-3) membrane protein. Additionally, we detected one perfect p53 RE within the promoter region and one imperfect p53 RE placed in the first intron of the gene encoding for CD59 (membrane inhibitor of reactive lysis/MIRL). The results of our investigation suggest that p53 may enhance the transcription of both CD59 and CD58 and imply a novel role for p53 as a direct regulator of the immune response.
ISSN:0306-9877
1532-2777
DOI:10.1054/mehy.2001.1476