Drug combinations with amoxycillin reduce selection of clarithromycin resistance during Helicobacter pylori eradication therapy

This study investigated the relationship between the drug combinations of the eradication regimens and the prevalence of acquired resistance to clarithromycin. Of 540 patients treated with anti- Helicobacter pylori regimens containing clarithromycin, 55 patients (31 males, mean age, 45.6 years) with...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2002, Vol.19 (1), p.67-70
Main Authors: Murakami, K, Fujioka, T, Okimoto, T, Sato, R, Kodama, M, Nasu, M
Format: Article
Language:English
Subjects:
2-Pyridinylmethylsulfinylbenzimidazoles
Amoxicillin - therapeutic use
Amoxycillin
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Benzimidazoles - therapeutic use
Biological and medical sciences
Clarithromycin - pharmacology
Clarithromycin resistance
Drug Resistance, Microbial
Drug Therapy, Combination
Enzyme Inhibitors - therapeutic use
Female
Helicobacter Infections - drug therapy
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - drug effects
Helicobacter pylori - isolation & purification
Humans
Lansoprazole
Male
Medical sciences
Metronidazole - therapeutic use
Microbial Sensitivity Tests
Middle Aged
Omeprazole - analogs & derivatives
Omeprazole - therapeutic use
Pharmacology. Drug treatments
Proton Pump Inhibitors
Rabeprazole
Retrospective Studies
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Summary:This study investigated the relationship between the drug combinations of the eradication regimens and the prevalence of acquired resistance to clarithromycin. Of 540 patients treated with anti- Helicobacter pylori regimens containing clarithromycin, 55 patients (31 males, mean age, 45.6 years) with failed eradication of H. pylori that was susceptible to clarithromycin before treatment were included. The E test was used to test for susceptibility to clarithromycin (minimum inhibitory concentration (MIC)
ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(01)00456-3