A BLAST from the Past: Ancient Origin of Human Sm Proteins

In this issue of Molecular Cell, Zhang et al. and Møller et al. independently report studies of the E. coli Hfq protein, revealing significant sequence similarities with human Sm proteins. Their findings suggest that Hfq, and the Sm and Sm-like (Lsm) proteins, may function in stabilizing interaction...

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Bibliographic Details
Published in:Molecular Cell 2002, Vol.9 (1), p.7-8
Main Authors: Donahue, William F, Jarrell, Kevin A
Format: Article
Language:English
Subjects:
Autoantigens - genetics
Autoantigens - metabolism
Carrier Proteins - genetics
Carrier Proteins - metabolism
Escherichia coli
Escherichia coli Proteins
Evolution, Molecular
Host Factor 1 Protein
Humans
Integration Host Factors
Protein Binding
Repressor Proteins - genetics
Repressor Proteins - metabolism
Ribonucleoproteins, Small Nuclear - genetics
Ribonucleoproteins, Small Nuclear - metabolism
RNA - genetics
RNA - metabolism
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
snRNP Core Proteins
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:In this issue of Molecular Cell, Zhang et al. and Møller et al. independently report studies of the E. coli Hfq protein, revealing significant sequence similarities with human Sm proteins. Their findings suggest that Hfq, and the Sm and Sm-like (Lsm) proteins, may function in stabilizing interactions between RNA molecules.
ISSN:1097-2765
1097-4164
DOI:10.1016/S1097-2765(02)00429-X