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A BLAST from the Past: Ancient Origin of Human Sm Proteins

In this issue of Molecular Cell, Zhang et al. and Møller et al. independently report studies of the E. coli Hfq protein, revealing significant sequence similarities with human Sm proteins. Their findings suggest that Hfq, and the Sm and Sm-like (Lsm) proteins, may function in stabilizing interaction...

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Published in:	Molecular Cell 2002, Vol.9 (1), p.7-8
Main Authors:	Donahue, William F, Jarrell, Kevin A
Format:	Article
Language:	English
Subjects:	Autoantigens - genetics Autoantigens - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Escherichia coli Escherichia coli Proteins Evolution, Molecular Host Factor 1 Protein Humans Integration Host Factors Protein Binding Repressor Proteins - genetics Repressor Proteins - metabolism Ribonucleoproteins, Small Nuclear - genetics Ribonucleoproteins, Small Nuclear - metabolism RNA - genetics RNA - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism snRNP Core Proteins Transcription Factors - genetics Transcription Factors - metabolism
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description	In this issue of Molecular Cell, Zhang et al. and Møller et al. independently report studies of the E. coli Hfq protein, revealing significant sequence similarities with human Sm proteins. Their findings suggest that Hfq, and the Sm and Sm-like (Lsm) proteins, may function in stabilizing interactions between RNA molecules.
doi_str_mv	10.1016/S1097-2765(02)00429-X
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subjects	Autoantigens - genetics Autoantigens - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Escherichia coli Escherichia coli Proteins Evolution, Molecular Host Factor 1 Protein Humans Integration Host Factors Protein Binding Repressor Proteins - genetics Repressor Proteins - metabolism Ribonucleoproteins, Small Nuclear - genetics Ribonucleoproteins, Small Nuclear - metabolism RNA - genetics RNA - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism snRNP Core Proteins Transcription Factors - genetics Transcription Factors - metabolism
title	A BLAST from the Past: Ancient Origin of Human Sm Proteins
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