The C(-260)>T gene polymorphism in the promoter of the CD14 monocyte receptor gene is not associated with acute myocardial infarction

CD surface molecules mediates cell activation and signaling. In particular, CD14 on blood monocytes mediate monocyte/macrophage activation by lipopolysaccharide. Lipopolysaccharide and its receptor, CD14, have been implicated in atherogenesis. It has been recently shown that a C(-260)T polymorphism...

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Published in:Clinical and experimental medicine 2003-11, Vol.3 (3), p.161-165
Main Authors: LONGOBARDO, M. T, CEFALU, A. B, NOTARBARTOLO, A, TRAVALI, S, AVERNA, M. R, PEZZINO, F, NOTO, D, EMMANUELE, G, BARBAGALLO, C. M, FIORE, B, MONASTERO, R, CASTELLO, A, MOLINI, V
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood
Cardiology. Vascular system
Coronary heart disease
Cytosine
Female
Gene Frequency
Genes
Genotype
Heart
Heart attacks
Humans
Lipopolysaccharide Receptors - genetics
Male
Medical sciences
Middle Aged
Myocardial Infarction - genetics
Myocardial Infarction - mortality
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Reference Values
Risk Factors
Smoking
Survival Analysis
T cell receptors
Thymine
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Summary:CD surface molecules mediates cell activation and signaling. In particular, CD14 on blood monocytes mediate monocyte/macrophage activation by lipopolysaccharide. Lipopolysaccharide and its receptor, CD14, have been implicated in atherogenesis. It has been recently shown that a C(-260)T polymorphism in the promoter of the CD14 receptor may be a risk factor for coronary artery disease. Recently this association has been questioned because no increased risk was found with the T allele, even in the homozygous state. In the present study we investigated a possible association between the C(-260)T polymorphism in the CD14 promoter and acute myocardial infarction. Two hundred and thrteen patients with and acute myocardial infarction 213 healthy controls were included in the study. Genotype frequencies of the C(-260)T polymorphism in the CD14 promoter were determined by polimerase chain reaction and the amplified product was cleaved with HaeIII. The frequency of the T allele was not significantly different in patients compared with controls. In this study we were not able to detect differences of frequency of the allele T (-260) in the promoter of the CD14 receptor gene in survivors of myocardial infarction and controls.
ISSN:1591-8890
1591-9528
DOI:10.1007/s10238-003-0020-1