Endothelial Dysfunction in Patients With Coronary Artery Disease: A Comparison of Three Frequently Reported Tests

BackgroundEndothelial dysfunction is useful in predicting future cardiovascular disease. At present several tests are available to test endothelial function: coronary diameter response to acetylcholine, forearm bloodflow (FBF) response to acetylcholine, and brachial artery flow-mediated dilative (FM...

Full description

Saved in:
Bibliographic Details
Published in:Journal of investigative medicine 2002-01, Vol.50 (1), p.19-24
Main Authors: Monnink, Stefan H. J., van Haelst, Paul L., van Boven, Ad J., Stroes, Erik S. G., Tio, René A., Plokker, Thijs W. M., Smit, Andries J., Veeger, Nic J. G. M., Crijns, Harry J. G. M., van Gilst, Wiek H.
Format: Article
Language:English
Subjects:
Acetylcholine
Aged
Brachial Artery - drug effects
Brachial Artery - physiopathology
Coronary Artery Disease - diagnosis
Coronary Artery Disease - physiopathology
Coronary Vessels - drug effects
Coronary Vessels - physiopathology
Diagnostic Techniques, Cardiovascular
Endothelium, Vascular - physiopathology
Female
Humans
Hyperemia - physiopathology
Male
Middle Aged
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BackgroundEndothelial dysfunction is useful in predicting future cardiovascular disease. At present several tests are available to test endothelial function: coronary diameter response to acetylcholine, forearm bloodflow (FBF) response to acetylcholine, and brachial artery flow-mediated dilative (FMD) response to postischemic hyperemia. This study aimed to compare the three most frequently reported endothelial function tests.MethodsTwenty-eight patients (19 males and nine females, mean age 57 years) referred for diagnostic coronary angiography were considered for endothelial function measurement in the coronary artery as well as in the forearm by FBF and FMD.ResultsAcetylcholine decreased the mean coronary diameter by 7.4% (SD 6.3%) and increased the mean FBF by 230% (SD 152%). Hyperemia increased the mean brachial diameter by 6.7% (SD 4.8%). The effect of acetylcholine on forearm resistance vessels was significantly related to the effect of acetylcholine on the coronary conduit vessels (P=0.039). Nonetheless, FMD was not related to FBF nor to the coronary response.ConclusionIn patients with mild coronary endothelial dysfunction, forearm vasoreactivity is related to the coronary response, provided that the same stimulus is used.
ISSN:1081-5589
1708-8267
DOI:10.2310/6650.2002.33513