Decreased insulin secretion and dyslipidemia coexist in subjects with impaired fasting glucose

We examined the fasting plasma glucose (FPG) levels at which the compensatory mechanism of pancreatic beta cells could act and dyslipidemia would occur in Japanese subjects. A 75 g oral glucose tolerance test (OGTT) was performed on 8923 subjects. The relationship between FPG and immunoreactive insu...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2002-02, Vol.55 (2), p.159-164
Main Authors: Ozaki, Kayo, Okubo, Masamichi, Mori, Hiroshi, Mito, Kazuyo, Hara, Hitoshi, Kohno, Nobuoki
Format: Article
Language:English
Subjects:
75 g oral glucose tolerance test
Adult
Aged
Aged, 80 and over
Associated diseases and complications
Biological and medical sciences
Blood Glucose - analysis
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Diabetes. Impaired glucose tolerance
Dyslipidemia
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Fasting
Female
Glucose Tolerance Test
Hormones. Endocrine system
Humans
Hyperlipidemias - complications
Impaired fasting glucose
Initial insulin secretion
Insulin - metabolism
Insulin Secretion
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Triglycerides - blood
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Summary:We examined the fasting plasma glucose (FPG) levels at which the compensatory mechanism of pancreatic beta cells could act and dyslipidemia would occur in Japanese subjects. A 75 g oral glucose tolerance test (OGTT) was performed on 8923 subjects. The relationship between FPG and immunoreactive insulin (IRI) was analyzed. The mean ΣIRI (sum of IRI during OGTT) level formed an inverted U-shaped curve with a peak level at FPG of 110–130 mg/dl. The mean IRI level 30 min after glucose administration (as a marker of initial insulin secretion) began to decrease at an FPG level of ≈100 mg/dl. The mean triglyceride level increased linearly with the elevation of the FPG level at FPG levels of 80–120 mg/dl. The mean high-density lipoprotein-cholesterol level decreased linearly with increasing FPG at FPG levels of 80–110 mg/dl. In Japanese, total insulin secretion during OGTT was affected at FPG levels >110–130 mg/dl. Moreover, subjects with FPG levels >110 mg/dl showed decreased initial insulin secretion and dyslipidemia. These results may indicate the necessity of intervention in individuals with impaired fasting glucose.
ISSN:0168-8227
1872-8227
DOI:10.1016/S0168-8227(01)00315-1