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Synthesis and evaluation of imidazo[1,5- a]pyrazines as corticotropin releasing hormone receptor ligands
A novel series of imidazo[1,5- a]pyrazines was synthesized and evaluated as corticotropin releasing hormone (CRH) receptor ligands. SAR studies focused primarily on dialkylamino side chain optimization. SAR of the aryl and small alkyl substituents was also explored. A novel series of imidazo[1,5- a]...
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Published in: | Bioorganic & medicinal chemistry letters 2002-02, Vol.12 (3), p.291-294 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A novel series of imidazo[1,5-
a]pyrazines was synthesized and evaluated as corticotropin releasing hormone (CRH) receptor ligands. SAR studies focused primarily on dialkylamino side chain optimization. SAR of the aryl and small alkyl substituents was also explored.
A novel series of imidazo[1,5-
a]pyrazines was synthesized and evaluated as corticotropin releasing hormone (CRH) receptor ligands. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/S0960-894X(01)00741-7 |