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Synthesis and evaluation of imidazo[1,5- a]pyrazines as corticotropin releasing hormone receptor ligands

A novel series of imidazo[1,5- a]pyrazines was synthesized and evaluated as corticotropin releasing hormone (CRH) receptor ligands. SAR studies focused primarily on dialkylamino side chain optimization. SAR of the aryl and small alkyl substituents was also explored. A novel series of imidazo[1,5- a]...

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Published in:Bioorganic & medicinal chemistry letters 2002-02, Vol.12 (3), p.291-294
Main Authors: Hartz, Richard A., Gilligan, Paul J., Nanda, Kausik K., Tebben, Andrew J., Fitzgerald, Larry W., Miller, Keith
Format: Article
Language:English
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Summary:A novel series of imidazo[1,5- a]pyrazines was synthesized and evaluated as corticotropin releasing hormone (CRH) receptor ligands. SAR studies focused primarily on dialkylamino side chain optimization. SAR of the aryl and small alkyl substituents was also explored. A novel series of imidazo[1,5- a]pyrazines was synthesized and evaluated as corticotropin releasing hormone (CRH) receptor ligands.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)00741-7