Outbreak of aseptic meningitis and mumps after mass vaccination with MMR vaccine using the Leningrad–Zagreb mumps strain

Data from routine surveillance during two mass immunisation campaigns (MIC) with Measles–mumps–rubella (MMR)vaccine using Leningrad–Zagreb mumps strain in two states in Brazil were analysed to estimate the risk of vaccine-related meningitis and mumps. Increase in the incidence of the two diseases wa...

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Bibliographic Details
Published in:Vaccine 2002-01, Vol.20 (7), p.1106-1112
Main Authors: da Cunha, Sérgio Souza, Rodrigues, Laura C, Barreto, Maurı́cio L, Dourado, Inês
Format: Article
Language:English
Subjects:
Adverse events
Brazil
Child
Child, Preschool
Disease Outbreaks
Humans
Infant
Measles virus
Measles-Mumps-Rubella Vaccine - adverse effects
Meningitis, Aseptic - epidemiology
MMR
Mumps - epidemiology
Mumps virus
Rubella virus
Vaccination - adverse effects
Vaccines
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Summary:Data from routine surveillance during two mass immunisation campaigns (MIC) with Measles–mumps–rubella (MMR)vaccine using Leningrad–Zagreb mumps strain in two states in Brazil were analysed to estimate the risk of vaccine-related meningitis and mumps. Increase in the incidence of the two diseases was observed in both states, 3 weeks after the vaccination campaigns. The estimated number of doses applied per one case of vaccine-related meningitis ranged from 6199 (95% CI: 4854–8058) to 19,247 (95% CI: 12,648–29,513) depending on the diagnostic criteria used and state. It was 300 doses (95% CI: 286–317) for each case of mumps. The implications for vaccination policy are discussed.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(01)00438-8