Antitumor Polycyclic Acridines. 8. Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium Salts

Two short routes to novel methylated pentacyclic quinoacridinium salts have been devised. New compounds display telomerase-inhibitory potency (

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Bibliographic Details
Published in:Journal of medicinal chemistry 2002-01, Vol.45 (3), p.590-597
Main Authors: Heald, Robert A, Modi, Chetna, Cookson, Jenny C, Hutchinson, Ian, Laughton, Charles A, Gowan, Sharon M, Kelland, Lloyd R, Stevens, Malcolm F. G
Format: Article
Language:English
Subjects:
Acridines - chemical synthesis
Acridines - chemistry
Acridines - metabolism
Acridines - pharmacology
Antineoplastic agents
Biological and medical sciences
Cell Nucleus - metabolism
Crystallography, X-Ray
DNA - chemistry
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - metabolism
Enzyme Inhibitors - pharmacology
Flow Cytometry
General aspects
Humans
Magnetic Resonance Spectroscopy
Medical sciences
Microscopy, Confocal
Models, Molecular
Pharmacology. Drug treatments
Solubility
Structure-Activity Relationship
Telomerase - antagonists & inhibitors
Telomerase - chemistry
Tumor Cells, Cultured
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Description
Summary:Two short routes to novel methylated pentacyclic quinoacridinium salts have been devised. New compounds display telomerase-inhibitory potency (
ISSN:0022-2623
1520-4804
DOI:10.1021/jm011015q