The presence of antiamoebic constituents in Psyllium husk

The crude extract of psyllium husk (ispaghula) and its active constituent (petroleum fraction) caused varying degrees of growth inhibition in three different species of Entamoeba, i.e. Entamoeba histolytica, E. invadens and E. dispar. The inhibitory effect of the crude extract was in the dose range...

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Bibliographic Details
Published in:Phytotherapy research 2002-02, Vol.16 (1), p.78-79
Main Authors: Zaman, Viqar, Manzoor, Syed Munazza, Zaki, Mehreen, Aziz, Nauman, Gilani, Anwar-ul-Hassan
Format: Article
Language:English
Subjects:
Amebicides - pharmacology
Animals
antiamboebic
Biological and medical sciences
Dose-Response Relationship, Drug
Entamoeba
Entamoeba - drug effects
Entamoeba histolytica - drug effects
General pharmacology
in vitro
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plantago ovata
Psyllium
psyllium husk
Seeds - chemistry
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Summary:The crude extract of psyllium husk (ispaghula) and its active constituent (petroleum fraction) caused varying degrees of growth inhibition in three different species of Entamoeba, i.e. Entamoeba histolytica, E. invadens and E. dispar. The inhibitory effect of the crude extract was in the dose range of 1–10 mg/mL, whereas a similar inhibitory effect was obtained with the petroleum fraction at a much lower dose (0.1–1.0 mg/mL), indicating that the active chemical(s) is/are concentrated in the petroleum fraction. These data support the traditional use of psyllium husk in amoebic dysentery. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.886