Rat retinal ganglion cells co-express brain derived neurotrophic factor (BDNF) and its receptor TrkB

The expression of brain derived neurotrophic factor (BDNF) and its preferred receptor (TrkB) in rat retinal ganglion cells (RGCs) have been determined in the present study. To identify RGCs retrograde labelling was performed with fluorogold (FG). Subsequently, retinas were immunostained with antibod...

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Bibliographic Details
Published in:Vision research (Oxford) 2002, Vol.42 (2), p.151-157
Main Authors: Vecino, Elena, Garcı́a-Grespo, David, Garcı́a, Mónica, Martinez-Millán, Luis, Sharma, Sansar C, Carrascal, Eliseo
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Eye and associated structures. Visual pathways and centers. Vision
Fluorescent Dyes
Fluorogold
Fundamental and applied biological sciences. Psychology
Ganglion cell
Neurotrophin
Rats
Rats, Sprague-Dawley
Receptor
Receptor, trkB - metabolism
Retina
Retinal Ganglion Cells - metabolism
TrkB
Vertebrates: nervous system and sense organs
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Summary:The expression of brain derived neurotrophic factor (BDNF) and its preferred receptor (TrkB) in rat retinal ganglion cells (RGCs) have been determined in the present study. To identify RGCs retrograde labelling was performed with fluorogold (FG). Subsequently, retinas were immunostained with antibodies to BDNF and TrkB. We found that all RGCs labelled with FG express both BDNF and its preferred receptor, TrkB. Moreover, displaced amacrine cells were also found to be immunolabelled by both antibodies. Thus BDNF/TrkB signalling in RGCs probably involves endogenous BDNF produced by the RGCs themselves.
ISSN:0042-6989
1878-5646
DOI:10.1016/S0042-6989(01)00251-6