Simple tumor profile chart based on cell kinetic parameters and histologic grade is useful for estimating the natural growth rate of hepatocellular carcinoma

Thirty-four untreated hepatocellular carcinomas (HCCs) with known growth rates were classified into 5 groups on a tumor profile chart based on their doubling time (DT), Ki-67–positive index (Ki-67-PI), apoptotic index (Apo-I), and histologic grade. The slow-growing HCCs (DT > 100 days) consisted...

Full description

Saved in:
Bibliographic Details
Published in:Human pathology 2002-01, Vol.33 (1), p.92-99
Main Authors: Nakajima, Tomoki, Moriguchi, Michihisa, Mitsumoto, Yasuhide, Katagishi, Tatsuo, Kimura, Hiroyuki, Shintani, Hiroyuki, Deguchi, Takeshi, Okanoue, Takeshi, Kagawa, Keizo, Ashihara, Tsukasa
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Apoptosis
Biological and medical sciences
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell Division
cell kinetics
Female
Gastroenterology. Liver. Pancreas. Abdomen
growth rate
hepatocellular carcinoma
Humans
Immunoenzyme Techniques
In Situ Nick-End Labeling
Ki-67 Antigen - metabolism
Kinetics
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
natural history
Neoplasm Staging
Retrospective Studies
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thirty-four untreated hepatocellular carcinomas (HCCs) with known growth rates were classified into 5 groups on a tumor profile chart based on their doubling time (DT), Ki-67–positive index (Ki-67-PI), apoptotic index (Apo-I), and histologic grade. The slow-growing HCCs (DT > 100 days) consisted of well-differentiated tumors with slight cell kinetic imbalance and were divided into groups A and B. Group A had Apo-I values
ISSN:0046-8177
1532-8392
DOI:10.1053/hupa.2002.30194